益经汤加减联合人工周期治疗卵巢储备功能减退的临床研究  

Clinical Study of Modified Yijing Decoction Combined with Artificial Periodic Therapy for the Treatment of Diminished Ovarian Reservation

作　　者：李娇娇 黄光荣 林雪寒 LI Jiao-Jiao;HUANG Guang-Rong;LIN Xue-Han(Shenzhen Bao’an Traditional Chinese Medicine Hospital Group Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518133 Guangdong,China)

机构地区：[1]广州中医药大学附属宝安中医院,广东深圳518133

出　　处：《广州中医药大学学报》2022年第9期2021-2027,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：深圳市宝安区医疗卫生基础研究项目(编号:2021JD167)。

摘　　要：【目的】观察益经汤加减联合人工周期治疗卵巢储备功能减退肾虚肝郁证患者的临床疗效。【方法】将76例卵巢储备功能减退肾虚肝郁证患者随机分为观察组和对照组,每组各38例。对照组给予人工周期治疗,观察组在对照组治疗的基础上给予益经汤加减治疗,疗程为3个月经周期。观察2组患者治疗前后性激素水平、子宫内膜厚度和中医证候积分的变化情况,评价2组患者的临床疗效及中医证候疗效。【结果】(1)临床疗效方面,治疗3个月经周期后,观察组的总有效率为92.11%(35/38),对照组为81.58%(31/38),组间比较,观察组的临床疗效优于对照组(P<0.05)。(2)中医证候疗效方面,治疗3个月经周期后,观察组的总有效率为89.47%(34/38),对照组为78.95%(30/38),组间比较,观察组的中医证候疗效优于对照组(P<0.05)。(3)性激素水平方面,治疗后,2组患者血清促卵泡刺激素(FSH)、促黄体生成素(LH)水平均较治疗前明显降低(P<0.05),血清雌二醇(E2)水平均较治疗前明显升高(P<0.05),且观察组对血清FSH、LH水平的降低作用及对血清E2水平的升高作用均明显优于对照组,差异均有统计学意义(P<0.05);而2组患者血清睾酮(Testo)、孕酮(Prog)和泌乳素(PRL)水平治疗前后及组间比较,差异均无统计学意义(P>0.05)。(4)子宫内膜厚度方面,治疗后,2组患者的子宫内膜厚度均较治疗前明显增加(P<0.05),且观察组对子宫内膜厚度的增加作用明显优于对照组(P<0.05)。(5)中医证候积分方面,治疗后,2组患者的中医证候积分均较治疗前明显降低(P<0.05),且观察组对中医证候积分的降低作用明显优于对照组(P<0.05)。【结论】益经汤加减联合人工周期可提高卵巢储备功能减退肾虚肝郁证患者的卵巢功能,改善患者的性激素水平,增加患者的子宫内膜厚度,改善患者的中医证候表现,提高患者的生活质量,临床疗效显著。Objective To observe the clinical efficacy of modified Yijing Decoction combined with artificial periodic therapy for the treatment of patients with kidney deficiency and liver depression type of diminished ovarian reserve(DOR).Methods Seventy-six DOR patients with kidney deficiency and liver depression syndrome were randomly divided into the observation group and the control group,38 cases in each group.The control group was given artificial periodic therapy,while the observation group was given modified Yijing Decoction combined with artificial periodic therapy.The treatment in both groups lasted for 3 menstrual cycles.The changes in sex hormone level,endometrial thickness and traditional Chinese medicine(TCM)syndrome scores of the two groups before and after treatment were observed,and then the clinical efficacy and TCM syndrome efficacy of the two groups were evaluated.Results(1)In terms of clinical efficacy,after 3 menstrual cycles of treatment,the total effective rate of the observation group was 92.11%(35/38),and that of the control group was 81.58%(31/38).The intergroup comparison showed that the clinical efficacy of the observation group was superior to that of the control group(P<0.05).(2)In terms of the TCM syndrome efficacy,after 3 menstrual cycles of treatment,the overall effective rate of the observation group was 89.47%(34/38),and that of the control group was 78.95%(30/38)in the control group.The intergroup comparison showed that the TCM syndrome efficacy in the observation group was superior to that in the control group(P<0.05).(3)After treatment,the serum follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels in both groups were significantly decreased compared with those before treatment(P<0.05),and the serum estradiol(E2)level was significantly increased compared with that before treatment(P<0.05).The effects on lowering serum FSH and LH levels and on increasing serum E2 level in the observation group were significantly superior to those in the control group,and the difference was

关 键 词：益经汤 人工周期 卵巢储备功能减退 肾虚肝郁证 性激素 子宫内膜厚度 中医证候积分 

分 类 号：R271.9[医药卫生—中西医结合]