补肾复方在绝经后骨质疏松症动物模型中的研究进展  

Research Progress of Kidney-tonifying Compounds in Animal Model of Postmenopausal Osteoporosis

作　　者：尹航 董博 康武林 袁普卫 刘德玉 YIN Hang;DONG Bo;KANG Wulin;YUAN Puwei;LIU Deyu(The First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712046,China;The Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712000,China)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712046 [2]陕西中医药大学附属医院,陕西咸阳712000

出　　处：《中医药导报》2022年第9期110-113,119,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：陕西省科技厅重点研发项目(2021SF419);咸阳市科技局社会发展科技重点研发计划(2020k02-109);陕西中医药大学学科建设创新团队项目(2019YL-02);全国中医临床特色技术传承人才培训项目(2019171)。

摘　　要：总结补肾复方对免疫调节细胞、激素或细胞因子表达、骨代谢及多种信号通路的调节作用,归纳补肾复方在绝经后骨质疏松症动物模型中的研究进展。补肾复方在绝经后骨质疏松症动物模型的治疗中发挥了积极的作用,可通过调节相关免疫细胞、血清炎症因子及信号通路,促进骨形成,抑制骨吸收,改善骨代谢水平,提高骨密度,防治绝经后骨质疏松症。This article summarizes the regulatory effect of kidney-tonifying compounds on immune regulatory cells,hormone or cytokine expression,bone metabolism and multiple signal pathways,and summarizes the research progress of kidney-tonifying compounds in animal models of postmenopausal osteoporosis.Kidney-tonifying compounds have played an active role in the treatment of animal models of postmenopausal osteoporosis.It can promote bone formation,inhibit bone absorption,improve bone metabolism,increase bone density,prevent and treat postmenopausal osteoporosis by regulating relevant immune cells,serum inflammatory factors and signal pathways.

关 键 词：绝经后骨质疏松症 补肾复方 动物模型 研究进展 

分 类 号：R255.6[医药卫生—中医内科学]