DNA去甲基化特征、功能及其在节肢动物中的研究现状  

Characteristics and function of DNA demethylation and its current studies in arthropods

作　　者：刘逸尘[1] 何雨欣 张亦陈[1] 孙金生[1] LIU Yichen;HE Yuxin;ZHANG Yichen;SUN Jinsheng(College of Life Sciences,Tianjin Normal University,Tianjin 300387,China)

机构地区：[1]天津师范大学生命科学学院,天津300387

出　　处：《天津师范大学学报（自然科学版）》2022年第5期1-9,共9页Journal of Tianjin Normal University：Natural Science Edition

基　　金：天津市自然科学基金资助项目(19JCYBJC29700,15JCZDJC33800);国家自然科学基金资助项目(31472299);水产生态及养殖重点实验室开放基金资助项目(TJAE2015005).

摘　　要：DNA甲基化作为表观遗传学中重要的修饰方式之一,其动态变化对生物生长发育和适应环境的能力具有显著影响.其中,DNA去甲基化途径在动物的发育、脑可塑性、基因组印记以及由环境胁迫引起的转录调控中有着重要作用.本文首先对DNA去甲基化的作用机制以及功能进行综述;其次,对其在节肢动物中的研究现状进行了介绍;最后进行总结和今后研究的展望.DNA methylation is one of the most important epigenetic modifications.Its dynamic changes have a significant influence on biological growth,development and the ability to adapt to the environment.DNA demethylation process plays an important role in animal development,brain plasticity,genomic imprinting and transcriptional regulation caused by environmental stress.The function and mechanism of DNA demethylation were reviewed in the first part and its research status in arthropods were subsequently introduced.Finally,the review was summerized and the future research was prospected.

关 键 词：表观遗传学 DNA去甲基化 DNA甲基化 节肢动物 

分 类 号：Q523[生物学—生物化学]