不同时机纤维支气管镜肺泡灌洗治疗小儿重症肺炎的效果评价  

Effect of fiberoptic bronchoscopy alveolar lavage at different times on children with severe pneumonia

作　　者：徐新齐[1] 高春利 马萍萍[1] Xu Xinqi;Gao Chunli;Ma Pingping(Department of Paediatrics,Jiaozuo People’s Hospital,Jiaozuo 454002,China;Department of Gynaecology and Obstetrics,Jiaozuo Maternal and Child Health Hospital,Jiaozuo 454002,China)

机构地区：[1]焦作市人民医院儿科,焦作454002 [2]焦作市妇幼保健院妇产科,焦作454002

出　　处：《中国实用医刊》2022年第14期42-45,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨不同时机纤维支气管镜肺泡灌洗治疗小儿重症肺炎的临床效果。方法抽取2020年2月至2021年2月焦作市人民医院收治的重症肺炎患儿86例,按随机数字表法分为A组与B组,每组43例。两组均采用纤维支气管镜肺泡灌洗治疗,B组治疗前病程<10 d,A组治疗前病程≥10 d。比较两组疗效、血氧分压(PaO_(2))水平、动脉血二氧化碳分压(PaCO_(2))水平、症状恢复时间、血清可溶性髓系细胞触发受体-1(sTREM-1)、高迁移率族蛋白-1(HMGB-1)及并发症发生率。结果A组总有效率(95.35%,41/43)高于B组(79.07%,34/43),P<0.05。治疗后,A组PaO2水平高于B组,PaCO_(2)水平低于B组(P<0.05)。A组体温恢复正常时间、撤机时间、症状消失时间及住院时间均短于B组(P均<0.05)。治疗后,A组血清sTREM-1、HMGB-1水平低于B组(P<0.05)。A组并发症发生率(4.65%,2/43)与B组(9.30%,4/43)比较差异未见统计学意义(P>0.05)。结论早期进行纤维支气管镜肺泡灌洗治疗重症肺炎患儿可改善患儿血气指标,帮助其恢复,缓解炎症,并发症发生率低,更有利于患儿病情好转。Objective To investigate the effect of fiberoptic bronchoscopy alveolar lavage at different times on children with severe pneumonia.Methods A total of 86 children with severe pneumonia treated in Jiaozuo People’s Hospital from February 2020 to February 2021 were selected and divided into group A and group B by random number table method,with 43 cases in each group.Both groups were treated by fiberoptic bronchoscopy alveolar lavage.The course of disease before treatment in the group B was less than 10 days,and the course of disease before treatment in the group A was greater than or equal to 10 days.The curative effect,PaO_(2) level,PaCO_(2) level,symptom recovery time,sTREM-1,HMGB-1 and complication rate were compared between the two groups.Results The total effective rate of the group A was 95.35%(41/43),higher than 79.07%(34/43)of the group B(P<0.05).After treatment,PaO2 level in the group A was higher than that in the group B,while PaCO_(2) level was lower than that in the group B(P<0.05).The recovery time of body temperature,weaning time,disappearance time of symptoms and hospitalization time in the group A were shorter than those in the group B(all P<0.05).After treatment,the levels of serum sTREM-1 and HMGB-1 in the group A were lower than those in the group B(P<0.05).There was no significant difference in the incidence of complications between the group A(4.65%,2/43)and the group B(9.30%,4/43),P>0.05.Conclusions Early fiberoptic bronchoscopy alveolar lavage in the treatment of severe pneumonia in children can improve blood gas indexes,be conductive to recovery,alleviate inflammation,reduce the incidence of complications,and help to the improvement of children’s condition,which is convenient for clinical promotion.

关 键 词：重症肺炎 纤维支气管镜 肺泡灌洗 疗效 

分 类 号：R725.6[医药卫生—儿科]