Ⅲ型干扰素抗病毒作用的研究进展  

Study on antiviral effect of typeⅢinterferon

作　　者：余纯纯(综述) 裴华(审校)[1] YU Chun-chun;PEI Hua(Department of Clinical Laboratory,the Second Affiliated Hospital of Hainan Medical University,Haikou 570311,Hainan Province,China)

机构地区：[1]海南医学院第二附属医院检验科,海南海口570311

出　　处：《微生物学免疫学进展》2022年第4期66-70,共5页Progress In Microbiology and Immunology

基　　金：国家自然科学基金(81860002);海南省重点研发项目(ZDYF2022SHFZ100)。

摘　　要：Ⅲ型干扰素(typeⅢinterferon,IFN-Ⅲ;亦称为IFN-λ)是2003年被发现的一种新型IFN,由IFN-λ1(IL-29)、IFN-λ2(IL-28A)、IFN-λ3(IL-28B)和IFN-λ4等细胞因子组成。IFN-λ通过与细胞膜上特异性受体IFN-λ受体1(IL-28RA)和IL-10R2结合,激活Janus激酶/信号转导与转录激活子等信号通路进行信号转导,从而发挥其生物学作用。IFN-λ是一种极具临床应用前景的细胞因子,与Ⅰ型IFN相比,在慢性丙型肝炎病毒(hepatitis C virus,HCV)感染中,能更好地改善病毒学应答以及提高病毒清除率,且不良反应更少。现就IFN-λ在消化道、肝脏以及呼吸道感染中的抗病毒作用作一概述。TypeⅢinterferon(IFN-λ)is a new type of interferon discovered in 2003,composed of four cytokines:IFN-λ1(IL-29),IFN-λ2 and IFN-λ3(respectively for IL-28 A and IL-28 B)and IFN-λ4.IFN-λexerts its biological role by binding to the cell membrane-specific receptors IFN-λR1(IL-28 RA)and IL-10 R2,activating signal pathways such as the Janus kinase/signal transducer and activator of transcriptions(JAK/STAT).IFN-λis a cytokine with great potential for clinical application.Compared with typeⅠinterferon,it can improve the virology response and increase virus clearance rate in chronic hepatitis C virus(HCV)infection with fewer adverse reactions.The antiviral effects of IFN-λon digestive tract,liver and respiratory tract infections are summarized in this paper.

关 键 词：Ⅲ型干扰素 信号转导 抗病毒作用 

分 类 号：R392[医药卫生—免疫学]