Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction ofα_(s1)-casein sensitized mice  

作　　者：Qianqian Zhang Xiaofeng Yu Linghan Tian Yanjun Cong Linfeng Li 

机构地区：[1]Beijing Advanced Innovation Center for Food Nutrition and Human Health,College of Food and Health,Beijing Technology and Business University,Beijing 100048,China [2]Department of Dermatology,Beijing Friendship Hospital,Beijing 100050,China

出　　处：《Food Science and Human Wellness》2023年第3期882-888,共7页食品科学与人类健康（英文）

基　　金：supported by the National Key Research and Development Program of China(2019YFC1605002);the National Natural Science Foundation of China(31872886)。

摘　　要：To investigate the anti-α_(s1)-casein allergy mechanism of two tea-derived polyphenols,epigallocatechin(EGC)and epigallocatechin gallate(EGCG),BALB/c mice were sensitized and challenged withα_(s1)-casein and nutritional intervention was given by EGC and EGCG during the sensitization provocation phase.The main evaluation indexes used were levels of mast cell proteases,histamine,and specific antibody immunoglobulin E(IgE),as well as cytokine secretion and pathological observation.The results showed that both EGC and EGCG significantly reduced levels of mast cell protease,histamine,specific IgE antibodies,and Th2 cytokines in allergic mice.The histopathology results showed that both EGC and EGCG markedly reduced the degree of lesions in the intestine,thymus,spleen,and lung.The conclusions from this study can provide a theoretical basis for the mechanism by which tea polyphenols regulate food allergens.

关 键 词：α_(s1)-casein EPIGALLOCATECHIN Epigallocatechin gallate Antianaphylaxis 

分 类 号：R285[医药卫生—中药学]