CX3CL1/FKN、CC16、GULP1在慢性阻塞性肺疾病合并肺气肿中的表达及相关性  

Expression and correlation of CX3CL1/FKN,CC16 and GULP1 in patients with chronic obstructive pulmonary emphysema

作　　者：柏发蕊 许栋 BAI Farui;XU Dong(Department of Respiratory Medicine,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Jiangsu,Suzhou 215000,China)

机构地区：[1]江苏省苏州市中西医结合医院呼吸内科,215000

出　　处：《河北医药》2022年第18期2752-2755,共4页Hebei Medical Journal

基　　金：苏州市科技计划项目(编号:SYSD2018204);苏州中西医结合医院科技项目(编号:YJ2018003)。

摘　　要：目的分析血清不规则趋化因子(CX3CL1/FKN)、Clara细胞分泌蛋白(CC16)、GULP1在慢性阻塞性肺疾病合并肺气肿(COPD合并肺气肿)中的表达及相关性。方法随机选取2019年1月至2021年1月收治的98例COPD患者为观察组,同期选取100例体检健康人员为对照组。检测CX3CL1/FKN、CC16、GULP1表达,分析CX3CL1/FKN、CC16、GULP1在COPD合并肺气肿中的表达及相关性。结果与对照组较,观察组患者FVC、FEV1、FEV1/FVC、CC16水平较低,CX3CL1/FKN、GULP1表达较高(P<0.05);且COPD合并肺气肿患者FVC、FEV1、FEV1/FVC、CC16水平低于COPD患者,CX3CL1/FKN、GULP1表达高于COPD患者,差异有统计学意义(P<0.05)。以CX3CL1/FKN、CC16、GULP1表达进行相关性分析,结果显示CX3CL1/FKN、GULP1与COPD合并肺气肿FVC、FEV1、FEV1/FVC呈负相关(P<0.05),与病情严重程度呈正相关(P<0.05);CC16与COPD合并肺气肿FVC、FEV1、FEV1/FVC呈正相关(P<0.05),与病情严重程度呈负相关(P<0.05)。多因素Logistic回归模型分析显示,CX3CL1/FKN、CC16、GULP1为影响COPD合并肺气肿发生的因素(P<0.05)。结论CX3CL1/FKN、CC16、GULP1表达水平与COPD合并肺气肿的发生、发展具有密切联系,且存在一定相关性,提示CX3CL1/FKN、CC16、GULP1表达变化可作为COPD合并肺气肿疾病诊断及预后评估的生物检测指标,对COPD合并肺气肿的预防及治疗干预具有重要裨益。Objective To investigate the expression and correlation of serum irregular chemokines(CX3CL1/FKN),Clara cell secretory protein(CC16),and GULP1 in patients with chronic obstructive pulmonary(COPD)complicated by emphysema.Methods A total of 98 patients with COPD who were treated in our hospital from January 2019 to January 2021 were enrolled as observation group,at the same time,100 healthy sbjects who underwent health examination were enrolled as control group.The expression levels of CX3CL1/FKN,CC16 and GULP1 were detected,and the correlation between the levels of CX3CL1/FKN,CC16,GULP1 and the occurrence of COPD complicated by emphysema was analyzed.Results The levels of FVC,FEV1,FEV1/FVC and CC16 in observation group were significantly lower than those in control group,however,the expressions levels of CX3CL1/FKN and GULP1 were significantly higher than those in control group(P<0.05).Moreover the levels of FVC,FEV1,FEV1/FVC and CC16 in patients with COPD complicated by emphysema were significantly lower than those of patients with COPD,but,the expression levels of CX3CL1/FKN and GULP1 were significantly higher than those of patients with COPD(P<0.05).In addition the correlation analysis showed that the expression levels of CX3CL1/FKN,CC16 and GULP1 were negatively correlated with those of FVC,FEV1 and FEV1/FVC in patients with COPD complicated by emphysema(P<0.05),however,which were positively correlated with the severity of the disease(P<0.05).Furthermore CC16 levels were positively correlated with those of FVC,FEV1 and FEV1/FVC(P<0.05),but,which were negatively correlated with the severity of the disease(P<0.05).Multivariate Logistic regression analysis showed that CX3CL1/FKN,CC16 and GULP1 were the factors affecting the occurrence of COPD complicated by emphysema(P<0.05).Conclusion The expression levels of CX3CL1/FKN,CC16 and GULP1 are closely correlated with the occurrence and development of COPD complicated by emphysema,which suggests that the expression levels of CX3CL1/FKN,CC16 and GULP1 may be regarded a

关 键 词：血清不规则趋化因子 CLARA细胞分泌蛋白 GULP1 慢性阻塞性肺疾病合并肺气肿 

分 类 号：R563[医药卫生—呼吸系统]