3,5-二叔丁基-4-羟基苄基甲基醚的合成研究  

Synthesis of 3,5-di-tert-butyl-4-hydroxybenzyl methyl ether

作　　者：郑晴 张晓利 杨叶伟 王震 张思思 程任 何观伟 刘卫涛 Zheng Qing;Zhang Xiaoli;Yang Yewei;Wang Zhen;Zhang Sisi;Cheng Ren;He Guanwei;Liu Weitao(The Northwest Research Institute of Chemical Industry Co.,Ltd.,Xi’an 710061,Shaanxi,China;Shaanxi Coal Chemical Engineering Technology ResearchCenter,Xi’an 710061,Shaanxi,China)

机构地区：[1]西北化工研究院有限公司,陕西西安710600 [2]陕西省煤化工工程技术研究中心,陕西西安710600

出　　处：《工业催化》2022年第9期68-72,共5页Industrial Catalysis

基　　金：陕西省重点研发计划项目(2019ZDLGY06-05)。

摘　　要：以多聚甲醛和2,6-二叔丁基苯酚为原料,合成3,5-二叔丁基-4-羟基苄基甲基醚,并用红外光谱(FT-IR)证实产物有预期结构。第一步多聚甲醛的解聚,正交实验结果表明最佳实验条件:在甲醇溶剂中叔丁醇钾为催化剂,解聚时间45 min,解聚温度60℃,解聚后的甲醛在溶液中含量38.1%;第二步醚化反应,正交实验结果表明最佳实验条件:醚化时间10 h,醚化温度90℃,n(2,6-二叔丁基苯酚)∶n(多聚甲醛)=1∶1.50,叔丁醇钾用量3.0%,3,5-二叔丁基-4-羟基苄基甲基醚收率87.6%。Using paraformaldehyde and 2,6-di-tert-butylphenol as raw materials,3,5-di-tert-butyl-4-hydroxybenzyl methyl ether is synthesized,and it is confirmed by infrared spectroscopy(FT-IR)that the product has the expected structure.In the first step of depolymerization of paraformaldehyde,the orthogonal experimental results show that the best experimental conditions are as follows:potassium tert-butoxide is used as the catalyst in methanol solvent,the depolymerization time is 45 min,and the depolymerization temperature is 60℃,and the depolymerized formaldehyde content in the solution is 38.1%.In the second step of etherification reaction,the orthogonal experiment results show that the best experimental conditions are etherification time 10 h,etherification temperature 90℃,n(2,6-di-tert-butylphenol)∶n(paraformaldehyde)=1∶1.50.When the dosage of potassium tert-butoxide is 3.0%,the yield of 3,5-di-tert-butyl-4-hydroxybenzyl methyl ether is 87.6%.

关 键 词：精细化学工程 3 5-二叔丁基-4-羟基苄基甲基醚 醚化反应 多聚甲醛解聚 正交实验 

分 类 号：TQ426.94[化学工程] TQ223.24