不同频次青藤碱注射治疗膝骨关节炎疗效比较  

Comparison of curative effects of different frequencies of sinomenine injections in the treatment of knee osteoarthritis

作　　者：马阿雪 鲁晓红 寇久社[3] 王东 阮珍 唐赛清 MA Axue;LU Xiaohong;KOU Jiushe;WANG Dong;RUAN Zhen;TANG Saiqing(The Second Clinical Medical College of Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China;The Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China;The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China;Medical Research Experiment Center of Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China)

机构地区：[1]陕西中医药大学第二临床医学院,陕西咸阳712046 [2]陕西中医药大学附属医院,陕西咸阳712000 [3]陕西中医药大学第二附属医院,陕西咸阳712000 [4]陕西中医药大学医学科研实验中心,陕西咸阳712046

出　　处：《现代中西医结合杂志》2022年第16期2240-2243,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：陕西省中医药管理局科研项目(LCPT085);陕西中医药大学2021年研究生创新实践能力提升项目(ZG024)。

摘　　要：目的探讨不同频次的青藤碱注射治疗膝骨关节炎的疗效。方法选取陕西中医药大学第二附属医院2021年11月-2022年1月诊治的60例膝骨关节炎患者,随机分为每日组和隔日组,每组30例。每日组给予青藤碱35 mg关节腔内注射,每日1次,共10次;隔日组给予青藤碱35 mg关节腔内注射,每2 d 1次,共5次。观察2组治疗前后西安大略和麦克马斯特大学骨关节炎指数评分(WOMAC)、疼痛视觉模拟评分法(VAS)评分和血清中白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平变化,记录2组不良反应发生情况。结果治疗后,2组患者WOMAC评分、VAS评分及血清中IL-1β和TNF-α水平均较治疗前显著降低(P均<0.05),每日组的WOMAC评分、VAS评分与隔日组比较差异均无统计学意义(P均>0.05),但每日组血清IL-1β和TNF-α水平显著低于隔日组(P均<0.05)。2组均无明显不良反应发生。结论不同频次的青藤碱注射治疗膝骨关节炎均能改善患者的症状并降低血清炎性因子水平,但每日注射下调血清炎性因子水平作用更显著。临床中可根据患者具体情况选取更为合适的治疗方法。Objective It is to explore the efficacy of different frequencies of sinomenine injections in the treatment of knee osteoarthritis.Methods A total of 60 patients with knee osteoarthritis who were diagnosed and treated in the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from November 2021 to January 2022 were selected and randomly divided into a daily group and an alternate-day group,with 30 cases in each group.The daily group was given sinomenine 35 mg by intra-articular injection,once a day,totally treated for 10 times;the alternate-day group was treated with sinomenine 35 mg by intra-articular injection,once every 2 days,totally treated for 5 times.The scores of Western Ontario and McMaster University Osteoarthritis Index(WOMAC),scores of Visual Analogue Scale(VAS),levels of serum interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were observed before and after treatment in the two groups,and the occurrence of adverse reactions in the two groups was recorded.Results After treatment,the WOMAC scores,VAS scores,and levels of serum IL-1βand TNF-αin the two groups were significantly lower than those before treatment(all P<0.05),there was no statistical significance in the the WOMAC scores,VAS scores between the daily group and alternate-day group(both P>0.05),but the levels of serum IL-1βand TNF-αin the daily group were significantly lower than those in the alternate-day group(P<0.05).There was no obvious adverse reaction occurred in both groups.Conclusion Different frequencies of sinomenine injections can improve the symptoms of patients and reduce the level of serum inflammatory factors in the treatment of knee osteoarthritis,but daily injection has a more significant effect on reducing the level of serum inflammatory factors.In clinical practice,a more appropriate treatment method can be selected according to the specific situation of the patient.

关 键 词：青藤碱 膝骨关节炎 频次 白细胞介素-Β 肿瘤坏死因子-Α 

分 类 号：R589.7[医药卫生—内分泌]