非编码RNA在术后认知功能障碍发病中的研究进展  

Role of noncoding RNA in the pathogenesis of postoperative cognitivedysfunction

作　　者：彭观发 王力峰 钟茂林[1] 梁伟东 叶军明[2] PENG Guanfa;WANG Lifeng;ZHONG Maolin;LIANG Weidong;YE Junming(The First Clinical Medical College/Affiliated Hospital,Gannan Medical University,Ganzhou 341000,China;不详)

机构地区：[1]赣南医学院第一临床医学院/附属医院,江西赣州341000 [2]赣南医学院,江西赣州341000

出　　处：《实用医学杂志》2022年第17期2128-2132,共5页The Journal of Practical Medicine

基　　金：江西省教育厅科技计划项目(编号:GJJ211514)。

摘　　要：术后认知功能障碍(postoperative cognitive dysfunction,POCD)是外科手术后出现的一种并发症,主要表现为精神错乱、焦虑、人格的改变以及记忆受损。POCD的确切发病机制尚不清楚,目前认为中枢神经炎症、氧化应激、细胞凋亡是导致POCD的主要原因。非编码RNA(non-coding RNA,nc RNA)是一类不具备蛋白编码功能、但对基因的转录和翻译起调控作用的基因转录产物,主要包括微小RNA、长链非编码RNA、环状RNA。近年来研究发现,非编码RNA广泛参与了POCD的发病过程。本综述总结了非编码RNA在术后认知功能障碍发病中的研究进展,以期为POCD的防治提供新的思路。Postoperative cognitive dysfunction(POCD)is a complication after surgery,with main manifes-tations of mental disorder,anxiety,personality changes and memory impairment.But the exact pathogenesis ofPOCD is not clear.At present,it is considered that central neuro-inflammation,oxidative stress and apoptosis arethe main causes of POCD.Noncoding RNA(nc RNA)is a kind of gene transcripts that does not have protein codingfunction but regulate gene transcription and translation,mainly including micro RNA,long noncoding RNA andcircular RNA.In recent years,studies have found that noncoding RNA is widely involved in the pathogenesis ofPOCD.In this review,we have summarized the research progress of noncoding RNA in the pathogenesis of postop-erative cognitive dysfunction,in order to provide new ideas for the prevention and treatment of POCD.

关 键 词：术后认知功能障碍 微小RNA 长链非编码RNA 环状RNA 

分 类 号：R614[医药卫生—麻醉学]