内皮特异性分子-1、纤维蛋白原在慢性阻塞性肺疾病急性加重期诊断及病情评估中的价值  

Value of endocan and fibrinogen in the diagnosis and disease course assessment of AECOPD

作　　者：彭贵鑫 管淑红[1] 周军 PENG Guixin;GUAN Shuhong;ZHOU Jun(Department of Respiratory and Critical Care Medicine,the Third Affiliated Hospital of Soochow University,Changzhou 213000,China;Department of Respiratory and Critical Care Medicine,Changzhou Maternal and Child Health Hospital,Changzhou Medical Center of Nanjing Medical University,Chang-zhou 213000,China;不详)

机构地区：[1]苏州大学附属第三医院呼吸与危重症医学科,江苏常州213000 [2]常州市妇幼保健院,南京医科大学常州医学中心,呼吸与危重症医学科,江苏常州213000

出　　处：《实用医学杂志》2022年第17期2198-2202,共5页The Journal of Practical Medicine

基　　金：常州市国际科技合作计划项目(编号:CZ20210024)。

摘　　要：目的分析内皮特异性分子-1(Endocan)、纤维蛋白原(Fib)水平在慢性阻塞性肺疾病急性加重期(AECOPD)的诊断、病情严重程度评估中的价值。方法收集苏大附三院2021年4月至2022年4月期间,在呼吸与危重症医学科进行救治的慢性阻塞性肺疾病(COPD)急性加重期患者79例为AECOPD组(根据疾病严重程度分为3个亚组),选同期门诊复诊的30例慢性阻塞性肺疾病稳定期(SCOPD)患者为SCOPD组,另选取在本院进行健康体检的30例为对照组。比较各组血清Endocan、Fib水平,分析上述因子在AECOPD诊断中的预测价值。结果AECOPD组和SCOPD组的Endocan、Fib水平均显著高于对照组(均P<0.05),且上述因子水平以AECOPD组最高。在AECOPD各亚组间的比较,发现Endocan、Fib水平差异均有统计学意义(均P<0.05),并随AECOPD级别增高而增加;受试者工作特征曲线分析结果显示,Endocan、Fib的曲线下面积(AUC)分别为0.832、0.729,二者联合检测的AUC更高,为0.855。结论血清Endocan、Fib的表达水平与AECOPD患者的疾病严重程度相关,可作为疾病诊断、病情评估的重要指标,且Endocan的诊断效能优于Fib。Objective To analyze the value of endothelial-specific molecule-1(Endocan)and fibrinogen(Fib)levels in the diagnosis and severity assessment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 79 patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)treated in the department of respiratory and critical care medicine from April 2021 to April 2022 were collected as a AECOPD group.Thegroup was then divided into three subgroups based on disease severity.30 patients with stable chronic obstructive pulmonary disease(SCOPD)who revisited our clinics during the same period were selected as a SCOPD group,and 30 individuals who underwent physical examination in our hospital were selected as acontrol group.Serum levels ofEndocan and Fib were comparedamong the groups,and the predictive value of the above factors in the diagnosis of AECOPD was analyzed.Results Levels of Endocan and Fib in the AECOPD and SCOPD groups were significantly higher than those in the control group(P<0.05 for all comparisons),demonstratingthe highest levelsin the AECOPD group.Levels of Endocan and Fib were significantly different among the AECOPD subgroups(P<0.05),and increased with the severitylevel of AECOPD.The receiver operating characteristic curve analysis results showed that the area under the curve(AUC)of Endocan and Fib were 0.832 and 0.729,respectively;and the AUC of the combined detection was higher,which was 0.855.Conclusions The expression levels of serum Endocan and Fib are related to the severity of AECOPD,which can be used as an important indicator for the diagnosis and assessment of disease course.The diagnostic efficiency of Endocan is better thanthat of Fib.

关 键 词：慢性阻塞性肺疾病急性加重期 内皮特异性分子-1 纤维蛋白原 新型冠状病毒肺炎 

分 类 号：R563[医药卫生—呼吸系统]