5-羟色胺受体在心肌缺血再灌注损伤中作用的研究进展  

Roles of 5-hydroxytryptamine receptor in myocardial ischemia-reperfusion injury:a review

作　　者：刘倩 黄勇祥 郑昌博 LIU Qian;HUANG Yong-xiang;ZHENG Chang-bo(School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for)

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500

出　　处：《中国药理学与毒理学杂志》2022年第7期521-528,共8页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81960662);云南省科技厅计划项目(2021001AT070154)。

摘　　要：心肌缺血再灌注损伤(MIRI)可导致心肌梗死、心律失常、心肌肥厚和心力衰竭等多种心脏疾病的发生,其主要损伤机制是引起细胞胞内Ca^(2+)超载、过氧化反应、炎症和细胞酸中毒等,造成心肌收缩功能障碍和心肌细胞过度挛缩,导致心肌细胞凋亡和坏死。5-羟色胺(5-HT)及其受体在MIRI中发挥了重要作用。不同5-HT受体亚型在MIRI中的调控作用机制不尽相同,如5-HT_(1A)受体介导氧化应激,5-HT_(1B/1D)受体介导炎症反应,5-HT_(2A)受体介导冠状动脉收缩,5-HT_(2B)受体介导心肌纤维化与瘢痕组织形成,5-HT_(3)受体介导心肌交感神经传入神经的激活,5-HT_(7)受体介导中性粒细胞迁移和炎症反应。本文简要介绍不同5-HT受体亚型在MIRI中心脏损伤作用机制,为以5-HT受体为靶点改善MIRI提供研究思路和参考依据。Myocardial ischemia-reperfusion injury(MIRI)can lead to myocardial infarction,arrhythmia,cardiac hypertrophy,heart failure and other heart diseases.The mechanism of damage of MIRI is that it causes intracellular Caoverload,peroxidation,inflammation and cytoacidosis,leading to myocardial systolic dysfunction and excessive contracture of myocardial cells that result in myocardial cel apoptosis and necrosis.5-Hydroxytryptamine(5-HT)and its receptors play an important role in MIRI.Different 5-HT receptor subtypes have different regulatory mechanisms in MIRI.For example,5-HTreceptor mediates oxidative stress,5-HTreceptor mediates inflammatory response,5-HTreceptor mediates coronary artery contraction,5-HTreceptor mediates myocardial fibrosis and scar tissue formation,5-HTreceptor mediates the activation of cardiac sympathetic afferent nerves,and 5-HTreceptor mediates neutrophil migration and inflammatory response.This paper outlines the mechanism of cardiac injury of different 5-HT receptor subtypes in MIRI in order to provide reference for improving MIRI by targeting 5-HT receptor.

关 键 词：心肌缺血再灌注损伤 5-羟色胺 5-HT受体 

分 类 号：R966[医药卫生—药理学]