急性冠脉综合征患者PCI术后短程双联抗栓后单用替格瑞洛的疗效观察  

Efficacy of antiplatelet therapy with ticagrelor monotherapy after short-term double antibody therapy in patients with acute coronary syndrome after PCI

作　　者：庞胜峰 张晶[2] 吴宁宁 李茹 曹军[1] 何胜虎[2] PANG Shengfeng;ZHANG Jing;WU Ningning;LI Ru;CAO Jun;HE Shenghu(Department of Cardiology,Taizhou Hospital of Traditional Chinese Medicine,Taizhou 225300,Zhejiang,China;Department of Cardiology,Subei People's Hospital of Jiangsu Province,Yangzhou 225002,Jiangsu,China)

机构地区：[1]泰州市中医院心血管病科,泰州225300 [2]江苏省苏北人民医院心内科,扬州225002

出　　处：《中国临床药理学与治疗学》2022年第9期1004-1009,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：江苏省卫生健康委科研课题(Z2018032)。

摘　　要：目的:观察经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)的急性冠脉综合征(acute coronary syndrome,ACS)患者短程双联抗栓后单用替格瑞洛抗血小板治疗的临床疗效。方法:选取2018年10月至2021年12月我院及江苏省苏北人民医院接受过PCI术的ACS患者172例,根据患者服药情况分为3组:A组(单纯替格瑞洛组)50例;B组(阿司匹林肠溶片+替格瑞洛组)62例;C组(阿司匹林肠溶片+硫酸氢氯吡格雷组)60例。观察患者术后再发心绞痛、支架内再狭窄、再次血运重建、心衰、出血等情况。结果:3组之间术后再发心绞痛、支架内再狭窄、再次血运重建、心衰、出血无统计学差异。结论:PCI术后短程双抗后单用替格瑞洛抗血小板治疗患者缺血性事件、心衰无增加,而且可减少出血风险。AIM:To observe the clinical efficacy of antiplatelet therapy with ticagrelor monotherapy after short-term double antibody therapy in patients with acute coronary syndrome(ACS)treated with percutaneous coronary intervention(PCI).METHODS:A total of 172 patients with ACS who had undergone PCI from October 2018 to April 2022 in our hospital and Subei People's Hospital of Jiangsu Province were selected and divided into three groups according to the patients'medication status:50 patients in group A(tegretol alone group);62 patients in group B(aspirin enteric coated tablets+tegretol group);and 60 patients in group C(aspirin enteric coated tablets+clopidogrel hydrogen sulfate group).The patients were observed for postoperative recurrent angina pectoris,in-stent restenosis,revascularization,heart failure,and bleeding.RESULTS:There were no significant differences in postoperative recurrent angina,in-stent restenosis,re-hematologic reconstruction,heart failure,and bleeding between the 3 groups.CONCLUSION:There is no increase in ischemic events,heart failure in patients treated with tegretol antiplatelet therapy alone after a short course of dual antibiotics after PCI and it reduces risk of bleeding.

关 键 词：经皮冠状动脉介入治疗 替格瑞洛 急性冠脉综合征 缺血性事件 出血 

分 类 号：R541[医药卫生—心血管疾病]