褪黑素人体网络机制及其临床应用  

Human body networks mechanisms of melatonin and its clinical applications

作　　者：邵明坤[2] 刘蓉[1] 孙品 关水[1] 廖炳灿 李莎 丛滔 梁凯 马辉[2] 孙长凯 SHAO Mingkun;LIU Rong;SUN Pin;GUAN Shui;LIAO Bingcan;LI Sha;CONG Tao;LIANG Kai;MA Hui;SUN Changkai(RECCE-TPM-HPM,School of Biomedical Engineering,Dalian University of Technology,Dalian 116024,Liaoning,China;Department of Pharmacy,the Second Hospital of Dalian Medical University,Dalian 116027,Liaoning,China;Department of Neurosurgery,Huashan Hospital of Fudan University,Shanghai 200040,China;Department of Hematology,the First Hospital of Dalian Medical University,Dalian 116011,Liaoning,China)

机构地区：[1]大连理工大学生物医学工程学院精准转化医学控制工程中心与精细化工国家重点实验室干细胞实验室,大连116024,辽宁 [2]大连医科大学附属第二医院药学部,辽宁大连116027 [3]复旦大学附属华山医院神经外科,上海200040 [4]大连医科大学附属第一医院血液科,辽宁大连116011

出　　处：《中国临床药理学与治疗学》2022年第9期1031-1040,共10页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家科技部《科技创新2030-“新一代人工智能”重大项目:新一代神经网络模型》(No.2018AAA0100300);国家自然科学基金(No.81801228);上海市《脑与类脑智能基础转化应用研究》重大科技专项资助(No.2018SHZDZX01)。

摘　　要：人体内的褪黑素主要是一种内源性吲哚胺类激素,具有多种生理功能。褪黑素除在治疗睡眠障碍方面发挥重要作用之外,还在治疗神经系统疾病、癌症、心血管系统疾病以及骨骼疾病等方面发挥重要作用。本文将基于褪黑素的人体网络机制和临床应用现状进行总结,探讨其进一步临床应用研究的重要问题聚焦点与方向。Melatonin is mainly an endogenous indoleamine hormone with many physiological functions.Melatonin not only plays an important role in the treatment of sleep disorders,but also plays an important role in the treatment of nervous system diseases,cancer,cardiovascular diseases,and bone diseases.In this paper,the human body networks mechanisms and the clinical applications of melatonin were summarized to provide reference for exploring the focus and direction of further clinical application research.

关 键 词：褪黑素 人体网络机制 临床应用 

分 类 号：R93[医药卫生—生药学]