冠心病患者AIP与生化指标的关系评估  

Evaluation of the correlation between AIP and biochemical indexes in patients with coronary heart disease

作　　者：陈泽芳 CHEN Ze-fang(Department of Cardiovascular Medicine,Puning People's Hospital,Puning 515300,China)

机构地区：[1]普宁市人民医院心血管内科,515300

出　　处：《中国实用医药》2022年第20期33-36,共4页China Practical Medicine

摘　　要：目的评估冠心病患者血浆致动脉粥样硬化指数(AIP)与生化指标的关系。方法采用回顾性研究方法,选取120例冠心病患者作为冠心病组,另选取137例体检健康者作为对照组。收集两组的一般临床资料、血脂指标、生化指标及冠状动脉造影结果等,并计算AIP。比较两组生化指标[空腹血糖(FPG)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBil)、血尿酸(UA)]水平、AIP和相关血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平;并分析冠心病患者AIP影响因素。结果冠心病组患者的FPG(5.93±2.21)mmol/L、UA(316.46±90.66)μmol/L均显著高于对照组的(5.09±0.68)mmol/L、(277.85±88.62)μmol/L,差异具有统计学意义(P<0.05);两组的AST、ALT、TBil水平比较差异无统计学意义(P>0.05)。冠心病组患者的TC(5.02±0.82)mmol/L、TG(0.99±0.42)mmol/L、LDL-C(2.48±0.66)mmol/L均显著高于对照组的(4.81±0.65)、(0.83±0.33)、(2.07±0.53)mmol/L,AIP(0.01±0.29)、HDL-C(1.16±0.21)mmol/L均显著低于对照组的(0.21±0.34)、(1.35±0.25)mmol/L,差异具有统计学意义(P<0.05)。多元逐步回归分析显示,UA、TG、HDL-C、LDL-C是AIP的独立危险因素(P<0.05)。结论冠心病患者的AIP与生化指标关系密切,分析冠心病危险因素并结合AIP指数有助于早期预测冠心病,并及时预防。Objective To evaluate the correlation between atherogenic index of plasma(AIP)and biochemical indexes in patients with coronary heart disease.Methods Using a retrospective study method,120 patients with coronary heart disease were selected as the coronary heart disease group,and 137 healthy subjects were selected as the control group.The general clinical data,blood lipid indexes,biochemical indexes and coronary angiography results of the two groups were collected,and AIP was calculated.Both groups were compared in terms of biochemical indicators[fasting plasma glucose(FPG),aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil),uric acid(UA)]levels,AIP and related blood lipid indicators[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]levels.The influencing factors of AIP in patients with coronary heart disease were analyzed.Results The FPG(5.93±2.21)mmol/L and UA(316.46±90.66)μmol/L in the coronary heart disease group were significantly higher than(5.09±0.68)mmol/L and(277.85±88.62)μmol/L in the control group,and the differences were tatistically significant(P<0.05).There was no statistically significant difference in the levels of AST,ALT and TBil between the two groups(P>0.05).In the coronary heart disease group,the TC(5.02±0.82)mmol/L,TG(0.99±0.42)mmol/L,and LDL-C(2.48±0.66)mmol/L were significantly higher than(4.81±0.65),(0.83±0.33)and(2.07±0.53)mmol/L in the control group;the AIP(0.01±0.29)and HDL-C(1.16±0.21)mmol/L were significantly lower than(0.21±0.34)and(1.35±0.25)mmol/L in the control group;all the differences were statistically significant(P<0.05).Multiple stepwise regression analysis showed that UA,TG,HDL-C and LDL-C were the independent risk factors for AIP(P<0.05).Conclusion AIP of patients with coronary heart disease is closely related to biochemical indicators.Analysis of coronary heart disease risk factors combined with AIP index can help to predict coronary heart disease ear

关 键 词：冠心病 血浆致动脉粥样硬化指数 生化指标 

分 类 号：R541.4[医药卫生—心血管疾病]