右美托咪定对大面积烧伤切痂植皮患者麻醉效果及应激反应的影响  

Effects of dexmedetomidine on anesthesia effect and stress response in patients with extensive burns requiring escharectomy and skin grafting

作　　者：杨艳华 YANG Yan-hua(Department of Anesthesiology,Chifeng Cancer Hospital of Inner Mongolia,Chifeng 024000,China)

机构地区：[1]内蒙古赤峰市肿瘤医院麻醉科,024000

出　　处：《中国实用医药》2022年第20期133-135,共3页China Practical Medicine

摘　　要：目的分析研究右美托咪定对大面积烧伤切痂植皮患者麻醉效果及应激反应的影响。方法60例大面积烧伤切痂植皮患者,依照随机数字表法分为对照组和观察组,各30例。观察组在麻醉诱导前及维持麻醉过程中予以右美托咪定进行干预,对照组在麻醉诱导前及维持麻醉过程中予以生理盐水进行干预。比较两组患者的麻醉效果、应激反应指标[心率(HR)、收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)]、手术相关指标和生活质量。结果观察组的总有效率为97%,高于对照组的77%,差异有统计学意义(P<0.05)。观察组HR(80.25±1.25)次/min、SBP(125.25±1.02)mm Hg(1 mm Hg=0.133 kPa)、DBP(75.25±1.02)mm Hg、MAP(85.25±1.25)mm Hg均低于对照组的(89.28±1.85)次/min、(131.52±2.52)mm Hg、(82.55±1.91)mm Hg、(92.25±1.78)mm Hg,差异有统计学意义(P<0.05)。两组患者的手术时间、术中出血量比较,差异无统计学意义(P>0.05)。观察组患者的社会功能、生理机能、生理功能、活力以及精神状态评分分别为(91.31±5.39)、(91.30±5.22)、(89.99±3.12)、(94.51±3.38)、(95.21±2.54)分,明显高于对照组的(81.26±5.37)、(80.68±5.44)、(81.64±3.29)、(83.66±4.59)、(89.11±3.22)分,差异有统计学意义(P<0.05)。结论在大面积烧伤切痂植皮中患者麻醉诱导前及维持麻醉过程中予以右美托咪定进行干预,能够有效帮助患者提高麻醉效果,帮助患者保持镇静,降低患者HR、血压以及MAP水平,提高患者生活质量,为患者带来益处,值得大力推广。Objective To analyze the effects of dexmedetomidine on anesthesia effect and stress response in patients with extensive burns requiring escharectomy and skin grafting.Methods A total of 60 patients with extensive burns requiring escharectomy and skin grafting were divided into the control group and the observation group according to random numerical table,with 30 cases in each group.The observation group was intervened with dexmedetomidine before induction of anesthesia and during the maintenance of anesthesia,and the control group was intervened with normal saline before the induction of anesthesia and during the maintenance of anesthesia.The anesthesia effect,stress response indicators[heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP)],surgery-related indicators and quality of life were compared between the two groups.Results The total effective rate in the observation group was 97%,which was higher than 77%in the control group,and the difference was statistically significant(P<0.05).The HR(80.25±1.25)times/min,SBP(125.25±1.02)mm Hg(1 mm Hg=0.133 kPa),DBP(75.25±1.02)mm Hg,MAP(85.25±1.25)mm Hg in the observation group were all lower than(89.28±1.85)times/min,(131.52±2.52)mm Hg,(82.55±1.91)mm Hg,(92.25±1.78)mm Hg in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant difference in the operation time and intraoperative blood loss between the two groups(P>0.05).The scores of social functioning,role-physical,physical functioning,vitality and mental state in the observation group were(91.31±5.39),(91.30±5.22),(89.99±3.12),(94.51±3.38),and(95.21±2.54)points,which were significantly higher than(81.26±5.37),(80.68±5.44),(81.64±3.29),(83.66±4.59),and(89.11±3.22)points of the control group,and the differences were statistically significant(P<0.05).Conclusion For patients with extensive burns requiring escharectomy and skin grafting,intervention with dexmedetomidine before induction of anes

关 键 词：右美托咪定 大面积烧伤切痂植皮 麻醉效果 应激反应 

分 类 号：R614[医药卫生—麻醉学]