Purifying chylous plasma by precluding triglyceride via carboxylated polyethersulfone microfiltration membrane  

作　　者：Yang Liu Qiu Han Guiliang Li Haibo Lin Fu Liu Gang Deng Dingfeng Lv Weijie Sun 

机构地区：[1]Ningbo Institute of Materials Technology&Engineering,Chinese Academy of Sciences,Ningbo 315000,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]The Ningbo Central Blood Station,Ningbo 315099,China [4]Department of Blood Transfusion,Ningbo First Hospital,Ningbo 315010,China

出　　处：《Chinese Journal of Chemical Engineering》2022年第9期130-139,共10页中国化学工程学报（英文版）

基　　金：financially supported by Natural Science Foundation of Ningbo City(2018A610026);Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(LR20E030002);Ten thousand plan-high level talents special support plan of Zhejiang province,China(ZJWR0108020);Youth Innovation Promotion Association of Chinese Academy of Science(2014258)。

摘　　要：Precluding the excessive lipoproteins from plasma rapidly and effectively is highly needed for biomedical detection and reducing plasma product scrap in blood donation stations.The current centrifugation procedure is high-cost and time-consuming.Herein,we fabricated an anionic microfiltration polyethersulfone(PES)membrane modified by interface swelling and implanting of acrylic acid(AA)for screening out large particle lipoprotein chylomicron(CM)and adsorbing cationic very low-density lipoproteins(VLDL).To improve the separation efficiency,a two-stage filtration through carboxylated polyethersulfone microfiltration membranes with the mean pore size of 0.45 and 0.22μm respectively were conducted.Attenuated total reflection Fourier transform infrared technique(ATR-FTIR),water contact angle(WCA),Zeta potential and scanning electron microscope(SEM)were employed to characterize the modified membrane.To test the effectiveness of this membrane,plasma flux and concentration variation of plasma components were examined to study the purification effectiveness.Furthermore,the hemocompatibility of modified membranes was tested to confirm its practicability on bloodcontacting materials.The carboxylated polyethersulfone microfiltration membrane shows its promising potential application to purify chylous plasma.

关 键 词：Chylous plasma CHYLOMICRONS Very low-density lipoproteins Carboxylated polyethersulfone microfiltration membrane 

分 类 号：TQ028.8[化学工程] R318.08[医药卫生—生物医学工程]