中老年人群血清炎症因子和血脂水平与抑郁症状的相关性研究  

Correlation between serum inflammatory factors and lipid levels and depressive symptoms in middle-aged and elderly people

作　　者：焦翔 郭丽阳 董莹莹[1] 马青艳[1] 王崴[1] 周莉娜 JIAO Xiang;GUO Li-yang;DONG Ying-ying;MA Qing-yan;WANG Wei;ZHOU Li-na(Department of Psychiatry,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院精神心理卫生科,710061

出　　处：《临床精神医学杂志》2022年第5期394-397,共4页Journal of Clinical Psychiatry

摘　　要：目的:探讨中老年人血清学炎症和代谢指标与抑郁症状之间的关系。方法:基线期纳入9543名年龄≥45岁的中老年人为研究对象,根据10条目流调中心用抑郁量表(CESD-10)评分分为无抑郁症状组(<12分,n=7161)和有抑郁症状组(≥12分,n=2382),比较血清炎症指标,如白细胞计数(WBC)、C反应蛋白(CRP)、胱抑素C(Cys C)及代谢指标如三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总胆固醇(TC)、葡萄糖(Glu)、尿酸(UA)、腰围及体质量指数(BMI)的差异,并分析与基线期、随访期CESD-10评分及其变化有关的因素。结果:基线期时,与无抑郁症状组相比,有抑郁症状组的受试者女性更多、年龄更大、WBC更高、HDL更高、UA更低、Cys C更高、腰围更细、BMI更小(P<0.05或P<0.01)。性别、年龄、WBC、HDL、UA、Cys C、腰围和BMI与基线期CESD-10评分相关(P均<0.01),性别、年龄、HDL、LDL、TC、UA、Cys C、CRP、腰围、BMI、基线期CESD-10评分与随访期CESD-10评分相关(P<0.05或P<0.01)。性别、TC和BMI是CESD-10评分增加的因素(P均<0.05)。结论:血清炎症水平和血脂水平改变与中老年人自我评价的抑郁症状有关。Objective:To explore the relationship between serum inflammatory factors and lipid levels and depressive symptoms in middle-aged and elderly subjects.Method:At baseline,9543 adults who aged≥45 years old were included in the study,and divided into non-depressive symptom group(<12,n=7161)and depressive symptom group(≥12,n=2382)according to scores on 10-item of Center for Epidemiologic Studies Depression Scale(CESD-10).The differences of serum inflammatory indicators including white blood cell count(WBC),C-reactive protein(CRP),cystatin C(Cys C)and metabolic indicators including triacylglycerol(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL),total cholesterol(TC),glucose(Glu),uric acid(UA),waist circumference and body mass index(BMI)were compared.Factors related to CESD-10 during the baseline and the follow-up were analyzed.Results:At baseline,participants in the depressive symptom group had more women,older age,higher WBC,higher HDL-C,lower UA,higher Cys C,smaller waist circumference and smaller BMI than those in the non-depressive symptom group(P<0.05 or P<0.01).Gender,age,WBC,HDL,UA,Cys C,waist circumference and BMI were correlated with CESD-10 score at baseline(all P<0.01).Gender,age,HDL,LDL,TC,UA,Cys C,CRP,waist circumference,BMI,and CESD-10 score at baseline were correlated with CESD-10 score in follow-up(P<0.05 or P<0.01).Gender,TC and BMI were factors correlated with an increase in CESD-10 score(all P<0.05).Conclusion:Changes in serum inflammation and lipid levels are related to self-rated depressive symptom in middle-aged and elderly people.

关 键 词：抑郁症状 炎症因子 血脂 社区研究 

分 类 号：R749.4[医药卫生—神经病学与精神病学]