基于收发一体聚焦超声换能器的浅表组织损伤实时监测研究  

Research on Real-Time Monitoring of Superficial Tissue Injury Based on Transceiver Integrated Focused Ultrasound Transducer

作　　者：谢伟 钱骏 田丽 谭坚文[1,2,3] 李发琪[1,2] 李雁浩 XIE Wei;QIAN Jun;TIAN Li;TAN Jianwen;LI Faqi;Li Yanhao(State Key Laboratory of Ultrasound in Medicine and Engineering,College of Biomedical Engineering,Chongqing Medical University,Chongqing 400016,China;Chongqing Key Laboratory of Biomedical Engineering,College of Biomedical Engineering,Chongqing Medical University,Chongqing 400016,China;National Engineering Research Center of Ultrasonic Medicine,Chongqing 401121,China)

机构地区：[1]重庆医科大学生物医学工程学院,超声医学工程国家重点实验室,重庆400016 [2]重庆医科大学生物医学工程学院,重庆市生物医学工程学重点实验室,重庆400016 [3]超声医疗国家工程研究中心,重庆401121

出　　处：《传感技术学报》2022年第7期996-1002,共7页Chinese Journal of Sensors and Actuators

基　　金：重庆市基础研究与前沿探索专项博士后科学基金项目(cstc2019jcyj-bshX0075);重庆市教委科学技术研究计划青年项目(KJQN202100466)。

摘　　要：在聚焦超声治疗浅表组织疾病过程中,尚无有效的手段对焦域组织损伤进行监控。以聚焦超声换能器为基础,构建了一套超声治疗和损伤监控一体化的超声脉冲回波信号监测系统。将获取的超声脉冲回波信号进行滤波,提取焦域范围内的回波信号包络,进而得到包络信号的积分值,用该积分数值大小来表征超声脉冲回波信号的强弱。计算出回波信号的相对变化值,从而分析出回波信号的相对变化与组织损伤的关系。离体牛肝实验结果表明:在相同辐照模式下,随着辐照回合数增加,回波信号相对变化值随之增大,组织损伤面积也随之增大。根据换能器接收的回波信号变化可以判断离体组织亚毫米级损伤的形成,且回波信号的强弱与离体组织损伤大小吻合度良好。这为聚焦超声治疗浅表组织疾病提供了一种具有一定应用前景的损伤监测方案和手段。In the treatment of superficial tissue diseases with focused ultrasound,there is no effective method to monitor focal area tissue damage.Based on the focused ultrasound transducer,a set of ultrasound pulse echo signal monitoring system that integrates ultrasound treatment and damage monitoring is constructed.The ultrasonic pulse echo signal is acquired and filtered,and the integral value of the echo signal envelope in the focal range is extracted.The integral value is used to characterize the strength of the ultrasonic pulse echo signal,and the relative change value of the echo signal is calculated,to analyze the relationship between the relative change of the echo signal and tissue damage.The experimental results of isolated bovine liver show that under the same irradiation mode,with the increase of the number of irradiation rounds,the relative change value of the echo signal increases,and the tissue damage area also increases.According to the change of ultrasonic pulse echo signal,the formation of sub-millimeter injury in isolated tissue can be judged,and the strength of echo signal is in good agreement with the size of injury in isolated tissue.This study provides a promising damage monitoring scheme and means for focused ultrasound in the treatment of superficial tissue diseases.

关 键 词：收发一体 聚焦超声换能器 脉冲回波 实时监测 

分 类 号：TH789[机械工程—仪器科学与技术]