Discovery of New Bohemamines and Synthesis of Methylene-Bridged Chimeric Derivatives through Natural Product Chimera Strategy  

作　　者：Rongxin Zhang Xiaotang Yan Shupeng Yin Weihong Wang Weiming Zhu Peng Fu 

机构地区：[1]Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003,China [2]Laboratory for Marine Drugs and Bioproducts,Pilot National Laboratory for Marine Science and Technology(Qingdao),Qingdao,Shandong 266237,China

出　　处：《Chinese Journal of Chemistry》2022年第12期1413-1421,共9页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(41806086,U1906213,41876172)。

摘　　要：Five new pyrrolizidine alkaloids,bohemamines J—N(1-5),were isolated from Streptomyces sp.CPCC 200497.Their structures were assigned based on detailed spectroscopic analysis and semisynthesis.Bohemamine J(1)possesses a new chimeric skeleton derived from bohemamine A(6)and phenylacetaldehyde.Inspired by the nonenzymatic formation mechanism of the methylene-bridged dimers isolated from this strain,we synthesized a series of chimeric derivatives(8,9,and 12-23)through natural product chimera strategy.Compounds 13,15,19,and 21 showed significant antioxidant activity.

关 键 词：Natural products Structure elucidation DIMERIZATION Pyrrolizidine alkaloids Biological activity 

分 类 号：O62[理学—有机化学]