转移因子辅佐枸地氯雷他定和氟替卡松联合治疗顽固性湿疹的疗效对比观察  

A comparative observation on therapeutic effect of transfer factor adjuvant desloratadine citrate and fluticasone in treatment of refractory eczema

作　　者：陶毅[1] TAO Yi(Department of Dermatology,Huangshan People’s Hospital,Huangshan,Anhui 245000,China)

机构地区：[1]黄山市人民医院皮肤科,安徽黄山245000

出　　处：《医药论坛杂志》2022年第15期40-43,共4页Journal of Medical Forum

摘　　要：目的观察转移因子辅佐枸地氯雷他定和氟替卡松联合治疗顽固性湿疹的疗效。方法回顾性分析2018年6月—2020年6月黄山市人民医院收治的97例顽固性湿疹患者的病历资料,根据不同治疗方法分为对照组49例,观察组48例,对照组采用枸地氯雷他定联合氟替卡松治疗,观察组在对照组基础上加用转移因子治疗,治疗为期1个月。比较两组患者治疗前后湿疹面积及严重程度指数(EASI)、皮肤病生活质量指标(DLQI)评分、临床疗效、LTB4和TSLP水平以及药物安全性。结果两组治疗后EASI评分和DLQI评分均低于治疗前,观察组两项评分均明显低于对照组(P<0.05)。观察组临床总有效率为87.76%,明显高于对照组的68.75%(P=0.001)。两组治疗后血清白三烯B4(leukotriene B4,LTB4)和胸腺基质淋巴细胞生成素(thymic stromal lym⁃phopoietin,TSLP)水平均低于治疗前,观察组上述指标明显低于对照组(P<0.05)。结论转移因子辅佐枸地氯雷他定联合氟替卡松能有效改善顽固性湿疹,增强治疗的临床疗效,这可能与降低血清LTB4和TSLP水平有关。Objective To observe the efficacy of transfer factor combined with desloratadine and fluticasone in the treat⁃ment of intractable eczema.Methods The medical records of 97 patients with intractable eczema from June 2018 to June 2020 were retrospectively analyzed.They were divided into 49 cases in the control group and 48 cases in the obser⁃vation group.The control group was treated with desloratadine combined with fluticasone.The observation group was treated with transfer factor on the basis of the control group for one month.The eczema area and severity index(EASI),skin disease quality of life index(DLQI)score,clinical efficacy,LTB4 and TSLP levels and drug safety were compared between the two groups before and after treatment.Results The EASI score and DLQI score of the two groups after treatment were lower than those before treatment,and the two scores of the observation group were significantly lower than those of the control group(P<0.05).The total clinical effective rate of the observation group was 87.76%,which was significantly higher than 68.75%of the control group(P=0.001).The levels of serum LTB4 and TSLP in the two groups after treatment were lower than those before treatment,and the above indexes in the observation group were signif⁃icantly lower than those in the control group(P<0.05).Conclusion Transfer factor combined with desloratadine and fluticasone can effectively improve the clinical efficacy of intractable eczema,which may be related to reducing the levels of serum LTB4 and TSLP.

关 键 词：顽固性湿疹 转移因子 枸地氯雷他定 氟替卡松 临床疗效 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]