Anti-proliferative Properties of Schinensilactone A,A Schinortriterpenoid with 7,8-Seco-1,8-cyclo Scaffold against Caco-2 by Inducing Cell Apoptosis from the Leaves of Schisandra chinensis  

作　　者：Yan Liu Guo-Zhen Liu Xiao-Mao Li Peng Jiang Yong-Gang Xia Hai-Xue Kuang Bing-You Yang 

机构地区：[1]Key Laboratory of Basic and Application Research of Beiyao(Heilongjiang University of Chinese Medicine),Ministry of Education,Harbin,Heilongjiang 150040,China

出　　处：《Chinese Journal of Chemistry》2022年第11期1331-1336,I0002,共7页中国化学（英文版）

基　　金：This work was financially supported by the_Heilongjiang Touyan Innovation Team Program and the National Natural Science Foundation of China(NSFC)(81473325).

摘　　要：A novel schinortriterpenoid(SNT),schinensilactone A(1),characterized by a unique 7,8-seco-1,8-cyclo-schisanartane scaffold,was isolated from the leaves of Schisandra chinensis(Turcz.)Baill,together with a new SNT(schinensilactone B,2)and two known(3,4).Their structures were elucidated using spectroscopy and X-ray diffraction.Furthermore,a hypothetical biosynthetic pathway for 1 was postulated due to its novel carbon skeleton.In addition,1 exhibited significant anti-proliferative activity against Caco-2 cells originat-ing from five different tumor cell lines,and its preliminary mechanism of action was investigated with respect to the expression of apoptosis-related proteins,including P53,Caspase 3,Bax,PUMA,and Bcl2.These biological activities would further our understanding of the food function of Schisandra chinensis leaves.

关 键 词：Schinensilactone A Schinensilactone B Natural products TERPENOIDS Biological activity 

分 类 号：O6[理学—化学]