非编码RNA在坏死性小肠结肠炎中作用的研究进展  

Research advances in the roles of noncoding RNAs in pathogenesis and prevention of necrotizing enterocolitis

作　　者：曹旭清 朱海涛[1] 沈淳[1] Cao Xuqing;Zhu Haitao;Shen Chun(Department of Pediatric Surgery,Children's Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China)

机构地区：[1]国家儿童医学中心,复旦大学附属儿科医院外科,上海201102

出　　处：《中华小儿外科杂志》2022年第8期759-764,共6页Chinese Journal of Pediatric Surgery

基　　金：国家自然科学基金面上项目(81873849);上海市自然科学基金项目(18ZR1405200)。

摘　　要：坏死性小肠结肠炎(necrotizing enterocolitis,NEC)是新生儿期一种危重的肠道疾病,多发于早产儿,病死率高且确切发病机制仍不明确。近年研究发现非编码RNA(non-coding RNA,ncRNA)尤其是微小RNA(micro RNA,miRNA)和长链非编码RNA(long non-coding,lncRNA)在包括NEC在内的肠道炎症性疾病的发生进展中发挥重要作用。此外,外泌体作为近年发现的一种潜在的新型NEC防治手段,其含有的大量ncRNA很可能是其发挥防治NEC作用的有效成分。本研究就非编码RNA在NEC发生中的作用及其在NEC防治研究中的进展进行综述,为研发新的防治方法提供思路。As a severe neonatal intestinal disease,necrotizing enterocolitis(NEC)affects preterm infants predominantly.NEC-related mortality has remained high and its pathogenesis is elusive.Recent studies have demonstrated that noncoding RNAs(ncRNA),especially micro RNAs(miRNA)and long noncoding RNAs(lncRNA),play important roles in the occurrence and progression of inflammatory intestinal diseases.Furthermore,as a new potential prevention for NEC,exosomes contain a huge quantity of effective ingredients,i.e.ncRNAs.This review summarized the roles of ncRNAs in pathogenesis and prevention of NEC so as to provide rationales for developing new control measures.

关 键 词：小肠结肠炎 坏死性 早产儿 非编码RNA 外泌体 

分 类 号：R722.1[医药卫生—儿科]