腹腔镜胆囊切除术后患者血管活性肠肽、白细胞介素-6与胆汁反流性胃炎的关系  

Relationship Between Vasoactive Intestinal Peptide,Interleukin-6 and Bile Reflux Gastritis in Patients After Laparoscopic Cholecystectomy

作　　者：朱春华 李发印 ZHU Chunhua;LI Fayin(Department of Gastroenterology,Jinshui District General Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市金水区总医院消化内科,河南郑州450000

出　　处：《河南医学研究》2022年第19期3545-3548,共4页Henan Medical Research

摘　　要：目的 探讨腹腔镜胆囊切除术后患者血管活性肠肽(VIP)、白细胞介素-6(IL-6)与胆汁反流性胃炎(BRG)的关系。方法 选择2019年10月至2021年10月在郑州市金水区总医院接受腹腔镜胆囊切除术的97例患者,根据术后是否发生BRG,分为BRG组(28例)和无BRG组(69例),另选同期60例体检健康者作为对照组。对比3组VIP、IL-6水平并分析其与腹腔镜胆囊切除术后患者发生BRG的相关性。结果 腹腔镜胆囊切除术后,BRG组患者血清VIP、IL-6水平高于无BRG组和对照组(P<0.05);Spearman相关分析显示,术后血清VIP水平、IL-6水平与BRG内镜分级中度相关(0.5<r<0.8,P<0.001);BRG组与无BRG组患者年龄、体质量指数比较,差异无统计学意义(P>0.05),BRG组不规律饮食人数占比、吸烟率、酗酒率及血清VIP、IL-6水平高于无BRG组(P<0.05);logistic回归分析得出,不规律饮食、吸烟、酗酒及高水平VIP、IL-6是腹腔镜胆囊切除术后发生BRG的高风险因素;受试者工作特征(ROC)曲线显示,血清VIP、IL-6评估腹腔镜胆囊切除术后患者发生BRG有较好的敏感度和特异度。结论 高水平VIP、IL-6及不规律饮食、吸烟、酗酒为腹腔镜胆囊切除术后发生BRG的高风险因素,对于辅助诊断腹腔镜胆囊切除术后发生BRG有一定价值。Objective To investigate the relationship between vasoactive intestinal peptide(VIP),interleukin-6(IL-6) and bile reflux gastritis(BRG) in patients after laparoscopic cholecystectomy.Methods Ninety-seven patients who underwent laparoscopic cholecystectomy in Jinshui District General Hospital of Zhengzhou from October 2019 to October 2021 were selected.According to whether BRG occurred after the operation,they were divided into BRG group(28 cases) and no BRG group(69 cases).Another 60 healthy people were selected as the control group.The levels of VIP and IL-6 in the three groups were compared,and to analyze their correlation with BRG in patients after laparoscopic cholecystectomy.Results After laparoscopic cholecystectomy,the levels of serum VIP and IL-6 in BRG group were higher than those in non BRG group and control group(P0.05).The proportion of patients with irregular diet,smoking rate,alcoholism rate,serum VIP and IL-6 in BRG group were higher than those in non BRG group(P<0.05).Logistic regression analysis showed that irregular diet,smoking,alcoholism,high level of VIP and IL-6 were the high risk factors of BRG after laparoscopic cholecystectomy.The receiver operating characteristic(ROC) curve showed that serum VIP and IL-6 had better sensitivity and specificity in assessing BRG after laparoscopic cholecystectomy.Conclusion High level of VIP,IL-6,irregular diet,smoking and alcohol abuse are the high risk factors of BRG after laparoscopic cholecystectomy,which has certain value in assisting diagnosis of BRG after laparoscopic cholecystectomy.

关 键 词：腹腔镜 胆囊切除术 胆汁反流性胃炎 血管活性肠肽 白细胞介素-6 

分 类 号：R619.9[医药卫生—外科学]