血清25-羟基维生素D水平与儿童过敏性鼻炎病情严重程度的关系  

Relationship between serum levels of 25-hydroxyvitamin D and severity of allergic rhinitis in children

作　　者：高楠[1] 刘羡伟 张永岗 高娟[1] 安良[1] GAO Nan;LIU Xian-wei;ZHANG Yong-gang;GAO Juan;AN Liang(Department of Clinical Laboratory,Xi'an Gaoxin Hospital,Xi’an 710010,Shaanxi,CHINA)

机构地区：[1]西安高新医院检验科,陕西西安710010

出　　处：《海南医学》2022年第19期2526-2529,共4页Hainan Medical Journal

摘　　要：目的 分析血清25-羟基维生素D [25(OH)D]水平与儿童过敏性鼻炎(AR)病情严重程度的关系,为儿童AR的防治提供参考依据。方法 选取2020年10月至2021年6月西安高新医院收治的100例AR患儿为研究对象,按照《儿童过敏性鼻炎诊疗-临床实践指南》分为中重度AR组45例和轻度AR组55例,以同期50例健康体检儿童作为对照组;对AR患儿进行过敏性鼻炎评分量表(SFAR)评分及症状视觉模拟量表(VAS)评分,检测三组受检者的血清25(OH)D及特异性免疫球蛋白E (IgE)水平;采用Spearman相关性分析血清25(OH)D、特异性IgE水平、SFAR评分、症状VAS评分之间的关系,采用受试者工作特征曲线(ROC)分析血清25(OH)D水平对中重度儿童AR的诊断效能。结果 中重度AR组与轻度AR组患儿的血清25(OH)D水平分别为(9.65±1.27) ng/mL、(15.70±3.18) ng/mL,明显低于对照组的(26.49±6.35) ng/mL,血清特异性IgE水平分别为(7.22±1.04) kU/L、(3.58±0.62) kU/L,明显高于对照组的(0.21±0.05) kU/L,而中重度AR组患儿的血清25(OH)D水平明显低于轻度AR组,血清特异性IgE水平明显高于轻度AR组,差异均有统计学意义(P<0.05);中重度AR组和轻度AR组患儿的SFAR评分[(10.25±1.13)分vs (6.27±2.33)分]和症状VAS评分[(8.96±0.58)分vs (5.59±2.20)分]比较,中重度AR组明显高于轻度AR组,差异均有统计学意义(P<0.05);经Spearman相关性分析结果显示,血清25(OH)D水平与血清特异性IgE水平(r=-0.638,P<0.05)、SFAR评分(r=-0.726,P<0.05)、症状VAS评分(r=-0.685,P<0.05)均呈明显负相关,血清特异性IgE水平与SFAR评分(r=0.710,P<0.05)、症状VAS评分(r=0.693,P<0.05)均呈明显正相关;血清25(OH)D水平诊断中重度儿童AR的曲线下面积(AUC)为0.875,最佳临界值为10.26 ng/mL,敏感性为89.50%,特异性为80.42%。结论 血清25(OH)D水平与儿童AR病情严重程度负相关,可用于AR的辅助诊断。Objective To discuss the relationship between serum levels of 25-hydroxyvitamin D [25(OH)D] and severity of allergic rhinitis(AR) in children.Methods A total of 100 AR children who were treated in Xi’an Gaoxin Hospital from October 2020 to June 2021 were selected as the research subjects.The children were divided into moderate-severe AR group(45 cases) and mild AR group(55 cases) according to the Guidelines for the Diagnosis and Treatment of Allergic Rhinitis in Children-Clinical Practice.Fifty healthy children undergoing physical examination in the hospital during the same time period were taken as the control group.The Scale for Anaphylactic Rhinitis(SFAR) and Visual Analogue Scale(VAS) were used to evaluate the AR children.The serum levels of 25(OH)D and specific immunoglobulin E(IgE) were detected in the three groups.Spearman correlation was used to analyze the relationship among serum levels of 25(OH)D,specific IgE,SFAR score,VAS score.Receiver operating characteristic curve(ROC) curve was used to analyze the diagnostic efficacy of serum levels of 25(OH)D in moderate-severe AR children.Results The serum levels of 25(OH)D was(9.65 ± 1.27) ng/mL in moderate-severe AR group and(15.70 ± 3.18) ng/mL in mild AR group,both significantly lower than(26.49±6.35) ng/mL in the control group;the serum level in moderate-severe AR group was significantly lower than that in mild AR group;the differences were statistically significant(P<0.05).The levels of specific IgE was(7.22±1.04) kU/L in moderate-severe AR group and(3.58±0.62) kU/L in mild AR group,both significantly higher than(0.21±0.05) k U/L in the control group;the level in moderate-severe AR group was significantly higher than that in mild AR group;the differences were statistically significant(P<0.05).The SFAR score and VAS score were(10.25±1.13) points and(8.96±0.58) points in moderate-severe AR group,significantly higher than(6.27±2.33) points and(5.59±2.20) points in mild AR group(P<0.05).Spearman correlation analysis showed that serum levels of 25(

关 键 词：儿童 过敏性鼻炎 25-羟基维生素D 特异性免疫球蛋白E 过敏性鼻炎评分量表 症状视觉模拟量表 相关性 

分 类 号：R729[医药卫生—儿科]