短TE校正同相位、小角度激发双回波成像评价非酒精性脂肪性肝病脂肪浸润程度  

Evaluation of fat infiltration in non-alcoholic fatty liver disease using dual-echo gradient-echo imaging with short TE corrected in phase and small flip angle excitation

作　　者：张德清[1] 王东东 胡云方 张俊安[1] 陈振松[1] 孟志华[1] ZHANG Deqing;WANG Dongdong;HU Yunfang;ZHANG Jun'an;CHEN Zhensong;MENG Zhihua(Imaging Center,Yue Bei People's Hospital,Shaoguan,Guangdong Province 512026,China;Department of Radiology,Zhengzhou People's Hospital,Zhengzhou 450053,China;Information Center,Yue Bei People's Hospital,Shaoguan,Guangdong Province 512026,China)

机构地区：[1]粤北人民医院影像中心,广东韶关512026 [2]郑州人民医院影像科,河南郑州450053 [3]粤北人民医院信息中心,广东韶关512026

出　　处：《实用放射学杂志》2022年第8期1284-1288,共5页Journal of Practical Radiology

基　　金：韶关市卫生和计划生育委员会科研项目(Y19054)。

摘　　要：目的探讨改良双回波成像技术检测非酒精性脂肪性肝病(NAFLD)脂肪浸润程度的价值.方法应用短TE校正同相位(IPc)、小反转角(30°)激发的改良双回波成像技术(Dual-corrected),氢质子磁共振波谱(^(1)H-MRS)技术分别测量69例NAFLD、24例健康志愿者(对照组)肝脏共108个感兴趣区(ROI)脂肪酸含量分数(%F).分析Dual-corrected与^(1)H-MRS测量%F一致性、可重复性及相关性.比较NAFLD与对照组、轻中重度浸润组%F_(Dual-corrected)间差异.结果2种方法组内相关系数(ICC)=0.962(P<0.001),相关系数(r)=0.967(P<0.001);直线回归方程%F_(Dual-corrected)=0.011+0.872%F_(MRS),决定系数(R^(2))=0.935,经回归方差分析及回归系数t检验,%F_(Dual-corrected)与%F_(MRS)呈正的直线相关关系,一致性及可重复性高.轻度组%F_(Dual-corrected)与对照组差异无统计学意义(P=0.676),与中度组、重度组比较差异均有统计学意义(P<0.001);中度组、重度组及对照组%F_(Dual-corrected)两两比较差异均有统计学意义(P<0.001).结论Dual-corrected能有效评价脂肪肝,%F_(Dual-corrected)能准确区分NAFLD中度、重度脂肪浸润.Objective To explore the value of corrected dual-echo gradient-echo imaging technique in detecting the degree of fat infiltration in non-alcoholic fatty liver disease(NAFLD).Methods Corrected dual-echo gradient-echo imaging with short TE corrected in phase(IPe)and small filp angle(30°)excitation(Dual-corrected)and hydrogen magnetic resonance spectroscopy(^(1)H-MRS)were used to measure the fatty acid fraction(%F)of 108 regions of interest(ROI)placed on liver of 69 NAFLD and 24 healthy volunteers(control group).The consistency,repeatability and correlation of %F between Dual-corrected and ^(1)H-MRS were analyzed.The differences of %F_(Dual-corrected) between NAFLD and control groups,and between mild-,moderate-and severe-infiltration groups were compared.Results The intraclass correlation coefficient(ICC)of the two methods was 0.962(P<0.001),and correlation coefficient(r)was 0.967(P<0.001).The linear regression equation was %F_(Dual-corrected)=0.011+0.872% F_(MRS),R^(2)=0.935(P<0.001).The regression analysis of variance and regression coefficient t-test showed there was a positive linear correlation between %F_(Dual-corrected) and %F_(MRS),with a high consistency and repeatability.There was no significant difference in %F poal-oreted between mild group and control group(P=0.676),but there was a significant difference between moderate group and severe group(P<0.001),and between moderate group,severe group and control group(multiple comparison,P<0.001).Conclusion Dual-corrected can effectively evaluate fatty liver,and %F_(Dual-corrected) can accurately distinguish moderate and severe fatty infiltration in NAFLD.

关 键 词：改良双回波成像 氢质子磁共振波谱 非酒精性脂肪性肝病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575[医药卫生—诊断学] R575.5[医药卫生—临床医学]