RhD--缺失型患者的血型血清学特征及临床意义分析  

Analysis of serological characteristics and clinical significance of RhD--patient

作　　者：强文[1] 瞿珍[1] 何鸣镝[1] 朱远雁[1] QIANG Wen;QU Zhen;HE Mingdi;ZHU Yuanyan(Wuhan Blood Center,Wuhan,430030,China)

机构地区：[1]武汉血液中心输血研究室,武汉430030

出　　处：《临床血液学杂志》2022年第8期595-597,601,共4页Journal of Clinical Hematology

基　　金：湖北省卫生健康委科研项目(No:WJ2019F019)。

摘　　要：目的探讨RhD--缺失型患者的血型血清学特征,分析抗-Rh17抗体产生及其临床意义。方法采用直接/间接凝集和吸收放散试验检测患者红细胞Rh抗原及血清中抗体,结合生育史和输血史进行分析。结果患者为B型RhD阳性,缺失C/c、E/e抗原,抗体鉴定强阳性,特异性为抗-Rh17抗体。结论RhD--缺失型个体妊娠或输血极易产生抗-Rh17高频抗体,输血前进行RhCcEe抗原鉴定,为患者制定合适的输血方案,对保障临床输血安全,提高救治率有重要意义。Objective To investigate the serological characteristics in patient with RhD--phenotype,and analyze the generation of anti-Rh17 antibody and its clinical significance.Methods The Rh antigen of erythrocytes and antibodies in serum were detected by agglutination test,absorption and eluate test,respectively.The clinical significance combined with the history of fertility and blood transfusion was analyzed.Results Detailed typing and antibody identification showed that the patient had a B RhD--phenotype with anti-Rh17 antibodies.Conclusion The individual with RhD--phenotype would be sensitized by Rh antigens and produce anti-Rh17 antibodies against highly prevalent antigens by blood transfusion or pregnancy.The identification of RhCcEe antigen before blood transfusion was great significant.It could contribute to formulate appropriate blood transfusion scheme for patients,ensuring the safety of clinical blood transfusion and improving the treatment rate.

关 键 词：RhD-- 抗-Rh17抗体 血清学特征 

分 类 号：R457.1[医药卫生—治疗学]