不同弯曲程度血管中适形贴壁支架的力学行为仿真  

Simulation of mechanical behavior of body-fitted stent in blood vessels with different curvature

作　　者：马晨阳 陈诗亮 张愉 乔爱科[1] MA Chenyang;CHEN Shiliang;ZHANG Yu;QIAO Aike(Faculty of Environment and Life,Beijing University of Technology,Beijing 100124)

机构地区：[1]北京工业大学环境与生命学部,北京100124

出　　处：《北京生物医学工程》2022年第5期441-446,共6页Beijing Biomedical Engineering

基　　金：国家自然科学基金项目(12172018);北京市教委-市自然科学基金联合项目(KZ202110005004)资助。

摘　　要：目的探讨不同弯曲程度的狭窄血管中适形贴壁支架的力学行为以及对贴壁不良的改善效果。方法首先建立三种不同弯曲程度(弯曲度T为0.1、0.05和0)的狭窄血管,采用三维投影的方法获得弯曲血管中的适形贴壁支架。模拟传统支架和适形贴壁支架在未完全钙化和完全钙化斑块血管中的压握、扩张过程,分析斑块上的应力水平并计算间隔距离和残留体积。结果与传统支架相比,适形贴壁支架对未完全钙化斑块上的最大Von Mises应力减少了约1 MPa,对完全钙化斑块减少了约3 MPa。对弯曲度T为0.1、0.05和0的完全钙化斑块血管的间隔距离均值分别减少了1.2%、4.3%和5.8%,残留体积分别减少了5.3%、42.5%和63.7%;对未完全钙化斑块血管的间隔距离均值分别减少了1.1%、5.6%和2.4%,残留体积分别减少了-5.7%、23.1%和46.7%。结论适形贴壁支架对斑块产生的Von Mises应力均低于传统支架,其对不同弯曲程度血管的贴壁不良情况均有所改善,且对弯曲程度较小的血管改善效果更好。Objective To explore the mechanical performance of body-fitted stent in stenotic vessels with different curvature and the improvement effect of stent malapposition.Methods Three kinds of stenotic vessels with different curvature(T=0.1,0.05 and 0)were modelled.The body-fitted stent in the curved vessel was structured by three-dimensional projection method.The crimping and expanding processes of conventional stent and body-fitted stent in vessels with cellular and calcified plaques were simulated.The Von Mises stress on the plaque was analyzed and the separation distance and residual volume were calculated.Results Compared with conventional stents,the maximum Von Mises stress of body-fitted stent on cellular plaque was reduced by about 1 MPa and that on calcified plaque was reduced by about 3 MPa,the mean separation distance of body-fitted stent to calcified plaques with curvature(T=0.1,0.05 and 0)decreased by 1.2%,4.3%and 5.8%respectively,and the residual volume decreased by 5.3%,42.5%and 63.7%respectively.The mean separation distance in cellular plaques decreased by 1.1%,5.6%and 2.4%,and the residual volume decreased by-5.7%,23.1%and 46.7%,respectively.Conclusions The Von Mises stress of body-fitted stent on plaque is lower than conventional stent.It can weaken the malapposition,and has a better effect on the vessels with small curvature.

关 键 词：弯曲血管 支架植入 支架贴壁不良 数值模拟 生物力学 

分 类 号：R318.01[医药卫生—生物医学工程]