含复方樟脑酊类药物致不良反应的文献分析  

Literature analysis of adverse reactions caused by drugs containing compound camphor tincture

作　　者：赵婷[1] 马佩杰[1] 舒文将 卢俊玮 董武[1] 鞠依珊 ZHAO Ting;MA Peijie;SHU Wenjiang;LU Junwei;DONG Wu;JU Yishan(Baoji Certral Hospital,Baoji 721008,China)

机构地区：[1]宝鸡市中心医院,陕西宝鸡721008

出　　处：《临床医学研究与实践》2022年第29期12-15,共4页Clinical Research and Practice

摘　　要：目的 分析含复方樟脑酊类药物致不良反应的文献,为临床合理用药提供参考。方法 检索中国知网数据库1990年1月至2020年11月含复方樟脑酊类药物致不良反应的文献,对患者年龄、性别、药品不良反应(ADR)发生时间、不同用药剂量下ADR发生情况、ADR主要临床表现及转归、过敏史、联合用药情况、遵医嘱服药情况进行分类、归纳、统计与分析。结果 共纳入文献31篇,涉及50例患者。ADR好发人群为0~9岁儿童及≥60岁老年人。ADR好发时间为用药60 min内。超剂量用药患者更易发生ADR。ADR主要临床表现为过敏反应及过敏性休克18例、中毒10例、成瘾5例;2例患者死亡,其余患者均好转或痊愈。明确过敏史21例,未提及过敏史29例。联合用药品种越多,患者越易发生ADR。自服药物患者发生ADR的风险高于遵医嘱服药患者。结论 加强含复方樟脑酊类药物监管及ADR监测,提高ADR防范意识,促进医-药-护-患共同协作,可减少ADR的发生。Objective To analyze the literature of adverse reactions caused by drugs containing compound camphor tincture,in order to provide reference for clinical rational drug use.Methods The literature of adverse reactions caused by drugs containing compound camphor tincture from January 1990 to November 2020 were searched in the database of China national knowledge internet,and the age,gender,occurrence time of adverse drug reaction(ADR),ADR occurrence under different drug doses,main clinical manifestations and outcomes of ADR,allergy history,combined drug use,and compliance with medical advice were classified,summarized,statistically and analyzed.Results A total of 31 literatures were included,involving 50 patients.The ADR prone population is children aged 0-9 years old and the elderly aged ≥ 60years old.The ADR peak time of onset was within 60 min of administration.Patients with overdose medication were more prone to ADR.The main clinical manifestations of ADR were allergic reaction and allergic shock in 18 cases,poisoning in10 cases,addiction in 5 cases;there were 2 cases of death,and improvement or recovery in other patients.There were 21cases with definite allergic history and 29 cases without mention of allergic history.The more varieties of combined drug use,the more prone patients are to develop ADR.The risk of ADR in patients taking drugs by themselves was higher than that in patients taking drugs by medical advice.Conclusion Strengthening the supervision of drugs containing compound camphor tincture and ADR monitoring,improving the awareness of ADR prevention,and promoting the cooperation between doctors,drugs,nurses and patients can reduce the occurrence of ADR.

关 键 词：含复方樟脑酊类药物 药品不良反应 文献分析 

分 类 号：R969.3[医药卫生—药理学]