达格列净联合利拉鲁肽对糖尿病肾病患者血清炎症因子水平及蛋白尿的影响  被引量:13

Effects of dapagliflozin combined with liraglutide on serum inflammatory factors level and proteinuria in patients with diabetic nephropathy

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作  者:贺巧艳[1] 白若玥 王湘[2] HE Qiaoyan;BAI Ruoyue;WANG Xiang(Yan'an University Affiliated Hospital,Yan'an 716000;Xi'an Medical University,Xi'an 710021,China)

机构地区:[1]延安大学附属医院,陕西延安716000 [2]西安医学院,陕西西安710021

出  处:《临床医学研究与实践》2022年第29期40-43,共4页Clinical Research and Practice

基  金:陕西省科技计划项目(No.2018SF-173)。

摘  要:目的 观察达格列净联合利拉鲁肽对糖尿病肾病患者血清炎症因子水平及蛋白尿的影响。方法 选择2019年3月至2021年6月我院接收的140例糖尿病肾病患者作为研究对象,根据治疗方案的不同将其分为对照组和观察组,各70例。对照组给予利拉鲁肽治疗,观察组在对照组基础上联合达格列净治疗。比较两组的血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、胰岛功能指标[空腹胰岛素(FINS)、餐后2 h胰岛素(2 h INS)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]、肾功能指标[血清肌酐(SCr)、血尿素氮(BUN)、微量白蛋白/肌酐比值(UACR)]、炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平及临床疗效。结果 治疗后,两组的FPG、2 h PG水平及HbA1c均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的FINS、2 h INS水平及HOMA-β均升高,HOMA-IR均降低,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的SCr、BUN及UACR水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的hs-CRP、IL-1β、TNF-α水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率为94.29%,显著高于对照组的82.86%,差异具有统计学意义(P<0.05)。结论 达格列净联合利拉鲁肽治疗糖尿病肾病的临床效果显著,能有效控制患者的血糖水平,改善胰岛功能,降低血清炎症因子,缓解或消除蛋白尿症状,提高肾功能指标。Objective To observe the effect of dapagliflozin combined with liraglutide on serum inflammatory factors leveland proteinuria in patients with diabetic nephropathy.Methods From March 2019 to June 2021,140 patients with diabetic nephropathy received in our hospital were selected as the research objects.According to the different treatment plans,the patients were divided into control group and observation group,with 70 cases in each group.The control group was treated with liraglutide,and the observation group was treated with dapagliflozin on the basis of the control group.The blood glucose indexes [fasting plasma glucose(FPG),2 h postprandial plasma glucose(2 h PG),glycosylated hemoglobin(HbA1c)],islet function indexes [fasting insulin(FINS),2 h postprandial insulin(2 h INS),homeostasis model assessment of insulin resistance(HOMA-IR),homeostasis model assessment of islet β-cell function(HOMA-β)],renal function indexes [serum creatinine(SCr),blood urea nitrogen(BUN),urinary albumin to creatinine ratio(UACR)],inflammatory factors [high-sensitivity C-reactive protein(hs-CRP),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)] levels and clinical efficacy were compared between the two groups.Results After treatment,FPG,2 h PG levels and HbA1c in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,the FINS,2 h INS levels and HOMA-β in the two groups increased,while HOMA-IR decreased,and those in the observation group were better than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of SCr,BUN and UACR in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P <0.05).After treatment,the levels of hs-CRP,IL-1β and TNF-α in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P

关 键 词:达格列净 利拉鲁肽 糖尿病肾病 炎症因子 蛋白尿 

分 类 号:R587.1[医药卫生—内分泌]

 

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