A comparative study of the midfoot structure of humans and mice by CT measurement:Implications for employing a mouse model to study Lisfranc injury  

作　　者：Chao Gao Ruokun Huang Wei Feng Yu Cheng Zhi Chen Zong-ping Luo Hongtao Zhang Jia Yu 

机构地区：[1]Department of Orthopedics,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215006,PR China [2]Orthopedic Institute,Medical College,Soochow University,Suzhou,Jiangsu 215007,PR China [3]Department of Foot and Ankle Surgery,Wuhan Fourth Hospital,Puai Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430033,PR China [4]Department of Radiology,Children's Hospital of Soochow University,Suzhou,Jiangsu 215003,PR China [5]Department of Orthopedics,Ningbo Sixth Hospital,1059 Zhongshan East Rd,Ningbo,Zhejiang,315000,PR China

出　　处：《Medicine in Novel Technology and Devices》2021年第3期162-167,共6页医学中新技术与新装备（英文）

基　　金：This work was supported by the National Key R&D Program of China(No.2018YFB1107000);the National Natural Science Foundation of China(11572211).

摘　　要：Although midfoot injury,especilly Lisfranc sprain,is a relative rare traumatic pathology,if overlooked or treated incorrectly,the damage will develop into chronic Lisfranc injury,which is characterized by lifelong residual symptoms.The differences in injury severity,healing rates,treatment plans,and patient adherence make pro-spective investigations of the pathogenesis of Lisfranc injury very dificult to conduct.The development of ananimal model that mimics the symptoms of humans with chronic Lisfranc injury has the potential to lessen thechallenges associated with prospective human research.Previous research has successfully used a mouse model to explore the biomechanics of the human ankle joint.However,it remains to be determined if the mouse model canmimic human midfoot functions based on their similarities in anatomical structure.In this study,the anatomicalstructure of the mouse and human midfoot were compared by CT scan.The animal image data were obtainedfrom 10 male C57BL/6J mice(20 feet)by micro-CT.The human data were obtained from six volunteers(six feet)by CT scanning.The three-dimensional skeletal structure of the midfoot was reconstr ucted,and the morphologicalparameters were measured by a plane projection method.There were no significant differences among thehindfoot adductus angle(mice:28.86±6.27°;human:25.45±2.70°),metatarsus aductus angle(mice:11.34±2.95°;human:11.48±3.97°),or the transverse arch angle(mice:111.77±4.70°;human:111.84±6.34°)between the mice and humans.The mice had a comparable Lisfranc joint complex architecture compared tohumans in both coronal and transverse planes.The lateral cuneiform was fused with the navicular bone in mice,which would provide better intrinsic stability than in humans.Future research is necessary to evaluate the mouse midfoot injury model and the similarities of their neuro-musculo-skletal systems with humans.

关 键 词：Midfoot injury Lisfranc injury Musculoskeletal anatomy RODENT Foot biomechanics 

分 类 号：R31[医药卫生—基础医学]