Effects of tissue heterogeneity on trabecular micromechanics examined by microCT-based finite element analysis and digital volume correlation  

作　　者：Jizhi Fu Haoye Meng Changhao Zhang Youjun Liu Duanduan Chen Aiyuan Wang Russell P.Main Haisheng Yang 

机构地区：[1]Department of Biomedical Engineering,Faculty of Environment and Life,Beijing University of Technology,Beijing,China [2]Institute of Orthopedics,Chinese PLA General Hospital,Beijing,China [3]School of Life Science,Beijing Institute of Technology,Beijing,China [4]Musculoskeletal Biology and Mechanics Lab,Department of Basic Medical Sciences,Purdue University,IN,USA [5]Weldon School of Biomedical Engineering,Purdue University,IN,USA

出　　处：《Medicine in Novel Technology and Devices》2021年第3期217-225,共9页医学中新技术与新装备（英文）

基　　金：This work was supported by National Natural Science Foundation of China[grant numbers 11702008,11832003];Beijing Natural Science Foundation of China[grant numbers 7202003];Beijing Municipal Education Commission Research Program[grant numbers KM202010005035].

摘　　要：Trabecular bone is natural material with heterogeneous tissue properties.The effect of tissue heterogeneity on the micromechanical behavior of trabecular bone is commonly evaluated by microCT-based finite element(microFE)analysis.Results from prior work remain inconclusive and lack of experimental validation.To address these issues,we combined microFE analysis with mechanical testing and microCT-based digital volume correlation(DVC),as a validation for the microFE approach.Porcine trabecular specimens were tested in compression as sequential microCT scans were taken.DVC was performed to extract“realistic”boundary conditions that were applied to microFE models,and to measure microstructural deformation and strain of the trabecular specimens.Heterogeneous and homogeneous microFE models of each trabecular specimen were created and compared with the experimentally measured microstructural displacement and strains.Results showed strong correlations between DVC-measured and microFE-predicted trabecular displacement and strain fields(R^(2)>0.9,p<0.05),regardless of heterogeneous or homogeneous material assignments.The heterogeneous and homogeneous models predicted similar magnitudes for maximum or minimum principal strains(R^(2)=1,p<0.05).However,incorporation of tissue heterogeneity decreased more than 16.5%in the overall stress level of the trabecular tissues.Regardless,very strong correlations were found between the heterogeneous and homogeneous model-predicted principal strains or stresses.These results together suggest that tissue heterogeneity may have little effect on microFE modeling of typical elastic displacement and strains in the trabecular bone,suggesting that homogeneous material models might be sufficient to predict general trabecular micromechanics.

关 键 词：Trabecular bone Tissue heterogeneity Finite element analysis MICROCT Digital volume correlation 

分 类 号：O17[理学—数学]