中药单体抑制金黄色葡萄球菌生物被膜形成的研究进展  

Research progress of inhibitory effect of traditional Chinese medicine monomer on biofilm formation of Staphylococcus aureus

作　　者：杨若琪 赵贵萍 王川东 王静[1] YANG Ruoqi;ZHAO Guiping;WANG Chuandong;WANG Jing(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji’nan 250355,China;College of Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;Microbial Technology Institute,Shandong University,Qingdao 266237,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]云南中医药大学中药学院,云南昆明650500 [3]山东大学微生物技术研究院,山东青岛266237

出　　处：《生物加工过程》2022年第5期537-544,共8页Chinese Journal of Bioprocess Engineering

基　　金：山东省中医药科技发展计划(2019-0027)。

摘　　要：金黄色葡萄球菌是一种临床上十分常见的病原细菌,其在医疗器械和植入物上形成的生物被膜赋予了金黄色葡萄球菌极强的抗生素耐药性,导致相关慢性感染难以彻底根除,从而对人类健康产生极大的威胁。天然产物来源的活性单体成分在抑制金黄色葡萄球菌生物被膜形成方面发挥了重要的作用,为抗细菌生物被膜研究提供了新策略。围绕金黄色葡萄球菌生物被膜形成过程中的分子调控机制,以及中药单体的抑制机制展开介绍,旨在为抑制细菌生物被膜感染的中医药基础研究提供理论参考。Staphylococcus aureus is a clinically common pathogenic bacteria.The biofilm formed on medical devices and implants contributes to the development of antibiotic resistance of S.aureus,which makes it difficult to eradicate related chronic infections and poses a great threat to human health.The active monomer components derived from traditional Chinese medicine play an important role in inhibiting the biofilm formation of S.aureus,which provides a new strategy for antibacterial biofilm research.This article focuses on the molecular regulation mechanism during the biofilm formation of S.aureus and the inhibitory mechanism of traditional Chinese medicine monomer, and aims to provide a theoretical reference for the basic research of traditional Chinese medicine to inhibit bacterial biofilm infection.

关 键 词：中药单体 金黄色葡萄球菌 生物被膜 调控机制 

分 类 号：Q93[生物学—微生物学]