胰岛移植治疗胰腺移植术后移植物失功3例  

Pancreatic islet transplantation for 3 cases of graft failure after pancreatic transplantation

作　　者：段金良 白芳 杨道朋 马雪 王树森[2] 孙鹏 龚金龙 林泽鹏 朱晓峰[1] 何晓顺[1] 胡安斌[1] Duan Jinliang;Bai Fang;Yang Daopeng;Ma Xue;Wang Shusen;Sun Peng;Gong Jinlong;Lin Zepeng;Zhu Xiaofeng;He Xiaoshun;Hu Anbin(Organ Transplantation Center,First Affiliated Hospital,Sun Yat-sen University,guangzhou 510080,guangdong,China;Tianjin First Central Hospital Transplant Center,Tianjin 300192,China.)

机构地区：[1]中山大学附属第一医院器官移植中心,广东广州510080 [2]天津市第一中心医院移植中心,天津300192

出　　处：《实用器官移植电子杂志》2022年第5期392-394,共3页Practical Journal of Organ Transplantation(Electronic Version)

基　　金：天津市“项目+团队”重点培养专项(XB202011)。

摘　　要：目的探讨胰岛移植治疗胰腺移植术后移植物失功的安全性及有效性,并总结文献经验。方法回顾性分析中山大学附属第一医院3例胰岛移植治疗胰腺移植术后移植物失功的临床资料,并随访6个月进行总结分析。结果胰腺移植术后移植物失功接受胰岛移植的3例患者术后胰岛功能良好,空腹C肽水平均较术前明显提升,出院前1例实现停用外源性胰岛素,其余2例胰岛素用量减少2/3以上,且均血糖平稳。结论对胰腺移植术后移植物失功的患者实施胰岛移植可以有效地补救性治疗糖尿病,且安全性高。Objective To investigate the safety and efficacy of islet transplantation after failed pancreas transplantation,and to summarize the literature experience.Methods The clinical data of 3 patients with islet transplantation after failed pancreas transplantation in the first Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed and followed up for 6 months.Results In the 3 patients who received islet transplantation after failed pancreas transplantation,the islet function was good after operation,the level of fasting C-peptide was significantly improved compared with that before surgery.All patients stopped using exogenous insulin or reduced the dosage by more than 2/3,and their blood glucose was stable.Conclusion islet transplantation after failed pancreas transplantation can be a remedial treatment for diabetes mellitus with high efficacy and safety.

关 键 词：胰岛移植 胰腺移植 糖尿病 

分 类 号：R657.5[医药卫生—外科学]