DNA修复基因与肾透明细胞癌相关性的研究进展  

Advances in DNA Repair Genes and Renal Clear Cell Carcinoma

作　　者：倪少滨[1] 单海涛 NI Shaobin;SHAN Haitao(Department of Urology,the Fist Afiliated Hospital of Harbin Medical University,Harbin,150000,China)

机构地区：[1]哈尔滨医科大学附属第一医院泌尿外科,哈尔滨市150000

出　　处：《医学分子生物学杂志》2022年第5期432-436,共5页Journal of Medical Molecular Biology

摘　　要：肾细胞癌(renal cell carcinoma,RCC)深刻且广泛地影响全人类,肾透明细胞癌(clear cell renal cell carcinoma,ccRCC)是其最主要病理亚型。在过去30年,肾细胞瘤的生物分子机制被不断挖掘,随着DNA修复途径及相关基因研究深入,逐渐发现了他们之间的联系。细胞总是暴露在各种损伤因素下,导致基因组损伤,若DNA修复系统功能缺陷,导致基因组不稳定,最终细胞凋亡或转变为癌细胞。DNA修复基因(DNA repair gene,DRG)与ccRCC在易感性,预后及治疗方面具有显著的生物学相关性,为进一步探索ccRCC与DNA损伤修复之间的分子机制,确定ccRCC新的分子标志物,寻找合适免疫抑制物治疗靶点奠定了一定的基础。Renal cell carcinoma(RCC)affects all human beings profoundly and extensively.Clear cell renal cell carcinoma(ccRCC)is the most common pathological subtype of RCC.In the past 30 years,the biomolecular mechanisms of RCC have been continuously explored.With the in-depth research on DNA repair pathways,the correlates between RCC and the DNA repair genes were gradually discovered.Cells were always exposed to various factor which could lead to the genome damages,and the DNA repair system helps to maintain the genome stability in that process.If the DNA repair system is defective,the genome wll become unstable,cells will undergo apoptosis or transform into cancer cells.This review focuses on the important biological correlates between DNA repair genes(DRG)and ccRCC in the susceptibility,prognosis,and treatment of cRCC.It could help lay a certain foundation for the further exploration of molecular mechanisms between DNA damage repair pathways and cRCC,the determination of new ccRCC molecular markers,and the finding of suitable immunosuppressive therapeutic targets.

关 键 词：肾透明细胞癌 DNA修复基因 生物学相关性 

分 类 号：R6[医药卫生—外科学]