Customized and in situ fenestrated stent-grafts:A reinforced poly-ε-caprolactone branch cuff designed to prevent type III endoleaks and enhance hemodynamics  

作　　者：Fujun Wang Chaojing Li Robert Guidoin Abedalwafa Mohammed Graeham Douglas Fan Zhao Guy Dionne Ze Zhang Haripriya Ramesh Lu Wang Mark Nutley 

机构地区：[1]Key Laboratory of Textile Science and Technology of Ministry of Education,College of Textiles,Donghua University,Shanghai,201620,China [2]Axe Medecine Regeneratrice,Centre de Recherche du CHU,and Departments of Surgery and Radiology,Universite Laval,Quebec,QC,Canada [3]Department of Engineering,University of Cambridge,Cambridge,UK [4]Joint Department of Biomedical Engineering,UNC/NCSU,Raleigh,NC,USA [5]Division of Vascular Surgery and Department of Diagnostic Imaging,University of Calgary,Peter Lougheed Centre,Calgary,AB,Canada

出　　处：《Medicine in Novel Technology and Devices》2021年第1期26-36,共11页医学中新技术与新装备（英文）

基　　金：This work was supported by“the Fundamental Research Funds for the Central Universities”(2232019D3-16)(China);the 111 Project 2.0“Biomedical Textile Materials Science and Technology”(B07024)(China);the Shanghai Science and Technology Support Project(18441902600)(China);the Engineering Research Center of Technical Textiles Ministry of Education(China);the Department of Surgery at Laval University(Quebec,Canada);the Fonds de Recherche de chirurgie vasculaire of the CHU(Quebec,Canada).The generous gift of device,by Medtronic and Vascutek is greatly acknowledged.The authors extend their appreciation to Boyin Qin,Yvan Douville,Pascal Rheaume,and Raymond Labbe.

摘　　要：Superior long-term anchorage of the bridging stent-grafts from the fenestrated main body endograft could be achieved with the addition of a flared cuff,capable of preventing the previously observed fabric fraying around the fenestration as a result of the balloon angioplasty of the seal zone.This novel stent cuff design will also facilitate more complete biointegration of the devices,eliminate the hemodynamic variation as well as significantly reduce the possibility of a Type III endoleak.The feasibility of this concept is demonstrated by observations made from in-situ tests performed in a Beta endograft design.Flared cuffs made of poly(ε-caprolactone)supported with a weft-knitted polyester structure can be manufactured with various configurations to optimize the transition from the main body of the endograft,thus preventing the currently marketed designs’hemodynamic perturbation while also promoting endograft biointegration.This concept represents an evolution in branch graft design,which may enhance the long-term durability of customized fenestrations and open new applications for in-vivo graft fenestration in the near future.Further ongoing investigation to optimize its structure,X-ray opacity,fixation to the flared stent,and material biocompatibility are still required to build upon this concept’s proof.

关 键 词：Flared cuff FENESTRATION Stent-grafts Poly(ε-caprolactone) Polyester fabrics 

分 类 号：TB3[一般工业技术—材料科学与工程]