隐匿性精子症患者精液精子和睾丸精子行ICSI治疗的临床结局比较  

Comparison of clinical outcomes of intracytoplasmic sperm injection treatment with ejaculated sperm and testicular sperm in patients with cryptozoospermia

作　　者：崔险峰[1] 丁攀[1] CUI Xianfeng;DING Pan(Reproductive Medical Center,Tianjin Central Hospital of Gynecology obstetrics,Tianjin 300100,China)

机构地区：[1]天津市中心妇产科医院生殖医学中心,300100

出　　处：《重庆医学》2022年第19期3289-3292,3297,共5页Chongqing medicine

基　　金：天津市医学重点学科(专科)建设项目(妇产科学TJYXZDXK-043A)。

摘　　要：目的比较隐匿性精子症患者采用精液精子和睾丸精子行卵胞浆内单精子注射(ICSI)的临床结局。方法回顾性分析2009年3月至2020年2月在该院行辅助生殖技术治疗的418例隐匿性精子症患者的临床资料,其中317例采用精液精子行ICSI治疗(精液精子组),101例采用睾丸提取精子行ICSI治疗(睾丸精子组),比较两组ICSI受精率、胚胎着床率、临床妊娠率及出生率等临床指标。结果精液精子组和睾丸精子组的ICSI受精率分别为60.1%和61.2%,差异无统计学意义(P>0.05);精液精子组和睾丸精子组的优质胚胎形成率分别为38.1%和45.2%,胚胎着床率分别为34.8%和54.0%,临床妊娠率分别为37.8%和51.5%,出生率分别为31.5%和44.6%,差异均有统计学意义(P<0.05)。结论隐匿性精子症患者行辅助生殖治疗时,采用睾丸精子较精液精子行ICSI可获得更优的临床结局。Objective To compare the clinical outcomes of intracytoplasmic sperm injection(ICSI)in ejaculated sperm and testicular sperm in the patients with cryptozoospermia.Methods The clinical data of 418 cases of cryptozoospermia treated by assisted reproductive techniques in this hospital from March 2009 to February 2020 were retrospectively analyzed,among them 317 cases conducted ICSI by adopting ejaculated sperm(ejaculated sperm group)and 101 cases conducted ICSI by extracting testicular sperm(testicular sperm group).The rates of ICSI fertilization,embryo implantation rate,clinical pregnancy rate and birth rate were compared between the two groups.Results The ICSI fertilization rates in the ejaculated sperm group and testicular sperm group were 60.1% and 61.2% respectively,and the difference was not statistically significant(P>0.05).The high quality embryo formation rates in the ejaculated sperm group and testicular sperm group were 38.1% and 45.2% respectively,the embryo implantation rates were 34.8% and 54.0% respectively,the clinical pregnancy rates were 37.8% and 51.5% respectively,the birth rates were 31.5% and 44.6% respectively,and the differences were statistically significant(P<0.05).Conclusion When conducting the assisted reproductive treatment in the patients with cryptozoospermia,adopting testicular sperm could obtain better clinical outcome than ejaculated sperm.

关 键 词：隐匿性精子症 精子 精液 睾丸 卵胞浆内单精子注射 妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]