慢性创面的血小板浓缩物制品治疗研究进展  

Research progress on platelet-rich concentrates in treatment of chronic wound

作　　者：陈新冲(综述) 黄广涛(审校) CHEN Xinchong;HUANG Guangtao(Department of Burn and Plastic Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China;Department of Burn and Plastic Surgery,The First Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong 518037,China)

机构地区：[1]遵义医科大学附属医院烧伤整形外科,贵州遵义563000 [2]深圳大学第一附属医院烧伤整形外科,广东深圳518037

出　　处：《重庆医学》2022年第19期3374-3378,3384,共6页Chongqing medicine

基　　金：国家自然科学基金项目(82172238,81801916,81960353);贵州省科技计划项目(黔科合基础[2020]1Y332)。

摘　　要：慢性创面的治疗是目前亟待解决的医疗难题之一。影响慢性创面愈合的原因有患者自身的健康状况、创面产生的始动因素及外部微环境的变化等。慢性创面的治疗周期较长,费用较高,效果较差且容易复发。常规修复方法效果不佳时可尝试采用生物疗法,以缩短创面愈合时长,提高愈合质量。作为一种促进创面愈合的新型疗法,血小板浓缩物(PC)在创面修复与再生医学领域有着广阔的应用前景。目前已有富血小板血浆(PRP)、富血小板纤维蛋白(PRF)及浓缩生长因子(CGF)三代产品。本文就PC的种类、各自特点及其在慢性创面治疗中的应用作一综述,了解PC在慢性创面治疗中的有效性及安全性,以便推广其在慢性创面中的应用。The treatment of chronic wound is one of the most difficult medical problems to solve at present.The factors affecting chronic wound healing include the patient’s own health status,the initial factors of wound formation and the change of external microenvironment.The treatment period of chronic wound is longer,the cost is higher,the effect is poor,and the recurrence is easy.When the conventional repair methods are not effective,the biological therapy can be tried to shorten the wound healing time and improve the quality of wound healing.As a new therapy to promote wound healing,the platelet-rich concentrates(PC)has a broad application prospect in the field of wound repair and regenerative medicine.At present,the three generation products such as platelet-rich plasma(PRP),platelet-rich fibrin(PRF)and concentrated growth factors(CGF)products are available.This article reviewed the types,characteristics and application of PC in the treatment of chronic wounds,in order to understand the efficacy and safety of PC in the treatment of chronic wounds and promote its application in chronic wounds.

关 键 词：慢性创面 微环境 血小板浓缩物 创面愈合 综述 

分 类 号：R641[医药卫生—外科学]