胶原蛋白的改性研究进展  

Research progress on modification of collagen

作　　者：周丹 尹伊秋 沈艳琴 武海良 姚一军 ZHOU Dan;YIN Yiqiu;SHEN Yanqin;WU Hailiang;YAO Yijun(School of Textile Science and Engineering,Xi′an Polytechnic University,Xi′an 710048,China)

机构地区：[1]西安工程大学纺织科学与工程学院,陕西西安710048

出　　处：《印染》2022年第10期78-81,共4页China Dyeing and Finishing

基　　金：陕西省三秦学者创新团队经费资助;陕西省教育厅专项科研计划项目(21JK0664)。

摘　　要：胶原蛋白分子的改性研究是制备胶原蛋白功能材料的关键。从交联改性和物理混合两个方面概述了胶原蛋白改性材料的研究进展,对比分析了物理交联、化学交联、共混改性制备的胶原蛋白改性材料的优缺点,认为物理改性可避免毒性物质进入胶原蛋白分子内,但交联度低,分子结构稳定性差;化学交联可提高交联度,但存在外源毒性物侵入的难题。通过物理改性与化学改性的协同作用,可有效降低胶原蛋白分子中残留的化学试剂,也保证了胶原蛋白改性材料的结构稳定性。The modification of collagen molecules is the key to the preparation of collagen functional materials.The research progress of collagen modified materials is summarized from two aspects of crosslinking modifica⁃tion and physical mixing.The advantages and disadvantages of collagen modified materials prepared by physi⁃cal crosslinking,chemical crosslinking and blending modification are compared and analyzed.It is believed that physical modification can prevent toxic substances from entering collagen molecules,but the crosslinking de⁃gree is low and the stability of molecular structure is poor.Chemical crosslinking can improve the degree of crosslinking,but there is a problem of foreign toxins invading.Through the synergistic effect of physical modifi⁃cation and chemical modification,the residual chemical reagents in collagen molecules can be effectively re⁃duced,and the structural stability of collagen modified materials can also be ensured.

关 键 词：胶原蛋白 改性 交联 天然高分子 纳米纤维支架 

分 类 号：TS199[轻工技术与工程—纺织化学与染整工程]