骨密度和肝脏脂肪含量与内脏脂肪含量相关性定量CT研究  

The QCT study of correlation among bone mineral density,liver fat content and visceral adipose tissue content

作　　者：祝凤玲 王植[1] 孟祥虹[1] 徐华[1] 仲玉侨 樊红星 ZHU Feng-ling;WANG Zhi;MENG Xiang-hong(Department of radiology,Tianjin Hospital of Tianjin,Tianjin 300211,China)

机构地区：[1]天津市天津医院放射科,天津300211 [2]天津医科大学医学影像学院医学技术,300211

出　　处：《放射学实践》2022年第10期1211-1216,共6页Radiologic Practice

基　　金：资助医疗卫生专家学者科技创新小微项目课题基金资助项目(20002);天津市天津医院科技基金资助项目(Tjyy2012)。

摘　　要：目的:探讨骨量正常和骨量减低以及骨质疏松患者的骨密度(BMD)、肝脏脂肪含量和内脏脂肪组织(VAT)含量的相关性。方法:本研究共纳入男受试者398人,年龄20-85岁,平均50.0±16.3岁。骨量正常组230人,骨量减低组118人,骨质疏松组50人。女受试者468人,年龄21-91岁,平均53.5±16.0岁,骨量正常组219人,骨量减低组127人,骨质疏松组122人。应用QCT测量受试者BMD、肝脏脂肪含量和VAT。采用单因素方差分析比较男女性3组间肝脏脂肪含量和VAT有无差别。对测量数据进行正态分布检验,采用Pearson相关评价BMD、肝脏脂肪含量和VAT的相关性。结果:男肝脏脂肪含量(F=1.248,P=0.288)3组无统计学差异;VAT(F=19.486,P<0.001)差异有统计学意义。女肝脏脂肪含量(F=6.686,P=0.001)、VAT(F=85.228,P<0.001)3组差异有统计学意义。男BMD与肝脏脂肪含量(P=0.258)不相关,BMD与VAT(R=-0.309,P<0.001)呈负相关;肝脏脂肪含量与VAT(R=0.450,P<0.001)呈正相关。女BMD与肝脏脂肪含量(R=-0.139,P<0.001)、BMD与VAT(R=-0.514,P<0.001)均呈负相关;肝脏脂肪含量与VAT(R=0.446,P<0.001)呈正相关。结论:男BMD与和VAT呈负相关,肝脏脂肪含量和VAT呈正相关,而女BMD与肝脏脂肪含量和VAT均呈负相关,肝脏脂肪含量和VAT呈正相关。Objective:To investigate the correlation among bone mineral density(BMD),liver fat content and visceral adipose tissue(VAT)content in patients with normal bone mass,low BMD and osteoporosis.Methods:398 males aged 20-85 years,with an average of 50.0±16.3,were included in this study.There were 230 normal bone mass cases,118 low BMD cases,and 50 osteoporosis cases.468 females aged 21-91 years were enrolled,with an average of 53.5±16.0.219 subjects were in the normal bone mass group,and 127 in the low BMD group,and 122 in the osteoporosis group.BMD,liver fat content and VAT were measured by QCT.One-way ANOVA was used to determine the differences of liver fat content and VAT among groups.The normal distribution of the data was tested,and the Pearson correlation was used for the correlation among BMD,liver fat content and VAT.Results:In the three groups of males,no statistical differences was observed in liver fat content(F=1.248,P=0.288);however,VAT was significant different among the three groups(F=19.486,P<0.001).In the three groups of females,significant difference was observed in liver fat content(F=6.686,P=0.001)and VAT(F=85.228,P<0.001).In the male group,BMD was not correlated with liver fat content(P=0.258),but negatively correlated with VAT(R=-0.309,P<0.001),and there was positive correlation between liver fat content and VAT(R=0.450,P<0.001).In the female group,BMD was negatively correlated with liver fat content(R=-0.139,P<0.001)and VAT(R=-0.514,P<0.001),and liver fat content was positively correlated with VAT(R=0.446,P<0.001).Conclusion:There is a negative correlation between BMD and VAT,a positive correlation between liver fat content and VAT in the male group.There is a negative correlation between BMD and liver fat content and VAT,and a positive correlation between liver fat content and VAT in the female group.

关 键 词：脂肪肝 腹内脂肪 体层摄影术 X线计算机 骨密度 

分 类 号：R814.4[医药卫生—影像医学与核医学] R336[医药卫生—放射医学] R575.5[医药卫生—临床医学] R329.55