微生态调节剂联合抗生素治疗小儿细菌性腹泻的效果观察  

Effect of microecological regulators combined with antibiotics in treatment of children with bacterial diarrhea:an observation study

作　　者：钟燕 朱红勇 杨露露 ZHONG Yan;ZHU Hongyong;YANG Lulu(People's Hospital of Ruijin City,Ruijin 342500,Jiangxi Province,China)

机构地区：[1]江西省瑞金市人民医院,瑞金市342500

出　　处：《内科》2022年第4期408-411,共4页Internal Medicine

摘　　要：目的探讨微生态调节剂联合抗生素治疗小儿细菌性腹泻的临床效果。方法纳入66例细菌性腹泻患儿为研究对象,随机将其分为对照组和试验组,每组33例。对照组患儿接受常规抗生素治疗,试验组患儿在对照组的基础上联合微生态调节剂治疗。两组均连续治疗1周。治疗1周后,比较两组患儿的临床疗效,以及外周血降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数水平情况;记录并比较患儿的退热时间、呕吐缓解时间、腹痛缓解时间、便检正常时间、住院时间、腹泻持续时间、腹泻总病程、治疗第3天与第6天的便次、家长满意度等。结果治疗前,两组患儿的外周血PCT、CRP、白细胞计数水平差异均无统计学意义(均P>0.05);治疗1周后,试验组的外周血PCT、CRP、白细胞计数水平均低于对照组,治疗总有效率高于对照组,退热时间、呕吐缓解时间、腹痛缓解时间、便检正常时间、住院时间、腹泻持续时间、腹泻总病程短于对照组,治疗第3天与第6天的便次少于对照组,家长对治疗的满意度高于对照组(均P<0.05)。结论微生态调节剂联合抗生素治疗小儿细菌性腹泻具有良好的效果,可有效地降低患儿机体炎性因子水平,缩短病程,减少便次,家长满意度较高。Objective To investigate the clinical effect of microecological regulators combined with antibiotics in the treatment of children with bacterial diarrhea.Methods A total of 66 children with bacterial diarrhea were enrolled as research subjects and randomly divided into a control group or a test group,with 33 cases in each group.The children in the control group were treated with routine antibiotics,based on which the children in the test group were treated with microecological regulators additionally.Both groups received treatment for 1 week.The followings were compared between the two groups,including the clinical efficacy and the peripheral blood procalcitonin(PCT),C-reactive protein(CRP),and white blood cell count levels after the 1-week treatment.The time to defervescence,time to vomiting relief,time to abdominal pain relief,time to normal stool test results,hospital stay,time for diarrhea,total course of diarrhea,the frequency of defection on the 3 rd and 6 th days of treatment,and parents′satisfaction were recorded and compared.Results Before the treatment,there was no significant difference in the peripheral blood PCT,CRP,or white blood cell count level between the two groups(all P>0.05).After the 1-week treatment,the test group had lower peripheral blood PCT,CRP,and white blood cell count levels,a higher total effective rate,shorter time to defervescence,time to vomiting relief,time to abdominal pain relief,time to normal stool test results,hospital stay,time for diarrhea,and total course of diarrhea,less defection frequency on the 3 rd and 6 th days of the treatment,and higher parents′satisfaction as compared with the control group(all P<0.05).Conclusion The combination of microecological regulators and antibiotics achieves superior efficacy in the treatment of children bacterial diarrhea,which can effectively reduce children’s inflammatory factors levels,shorten the disease course,decrease the defection frequency,and obtain high satisfaction of parents.

关 键 词：微生态调节剂 抗生素 小儿细菌性腹泻 降钙素原 C反应蛋白 

分 类 号：R725.7[医药卫生—儿科]