肠通膏穴位贴敷对慢性肾脏病患者消化道并发症的效果  

Effect of acupoint application of Changtong ointment on gastrointestinal complications in patients with chronic kidney disease

作　　者：罗琪[1] 任继刚[2] 敬剑英[3] 袁红梅[4] 蒙淳 张和平[3] LUO Qi;REN Jigang;JING Jianying;YUAN Hongmei;MENG Chun;ZHANG Heping(Outpatient Department,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Traditional Chinese Medicine,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Nephrology,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Ultrasongography,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Medical Record Statistics,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院门诊部,四川南充637000 [2]川北医学院附属医院中医科,四川南充637000 [3]川北医学院附属医院肾内科,四川南充637000 [4]川北医学院附属医院超声科,四川南充637000 [5]川北医学院附属医院病案统计科,四川南充637000

出　　处：《西部医学》2022年第10期1537-1541,共5页Medical Journal of West China

基　　金：四川省卫生健康委员会课题项目(19ZD006);南充市2019年市校合作科研专项重要技术公关项目(19SXHZ0439)。

摘　　要：目的探讨肠通膏穴位贴敷对慢性肾脏病患者消化道并发症的效果。方法选择2021年1月~2021年10月在我院肾病内科进行住院治疗的95例第3~5期慢性肾脏病伴消化道并发症患者作为研究对象,用随机排列的方法分为对照组(n=47)和观察组(n=48),其中对照组应用常规的治疗方法,观察组在此基础上增加肠通膏贴敷治疗,治疗2周后对两组患者的胃肠道症状、胃肠激素、肾脏功能、满意度等多维度进行对比分析。结果治疗前,两组患者胃肠道症状量表(GSRS)评分比较、血清生长抑素(SS)和血管活性肠肽(VIP)、胃动素(MOT)、肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白(24 h UTP)比较,差异无统计学意义(P>0.05)。干预2周后,观察组患者的胃肠道症状量表(GSRS)评分、胃动素(MOT)含量水平、胃肠功能恢复正常时间、Scr、24 h UTP水平均低于对照组(P<0.05);观察组患者满意度高于对照组(P<0.05);两组患者治疗前后BUN、生长抑素(SS)和血管活性多肽(VIP)含量无明显改变,差异无统计学意义(P>0.05)。结论肠通膏穴位贴敷治疗3~5期慢性肾脏病伴有消化道并发症的患者,可有效减轻其胃肠反应症状,降低患者的胃肠激素水平,提升患者满意度,临床未产生明显不良反应,可供临床借鉴。Objective To explore the effect of acupoint application of Changtong ointment on gastrointestinal reaction in patients with chronic kidney disease.Methods 95 patients with stage 3-5 chronic kidney disease hospitalized in Department of Nephrology of our hospital from January 2021 to October 2021 were selected as the research subject.They were randomly divided into two groups:the control group(n=47)and the observation group(n=48).The control group was treated with conventional treatment methods,and the observation group was treated with Changtong ointment.After 2 weeks of treatment,the gastrointestinal symptoms,gastrointestinal hormones,renal function analysis of satisfaction and other dimensions were compared.Results Before treatment,there was no statistically significant difference in the scores of gastrointestinal symptom scale(GSRS),serum somatostatin(SS),vasoactive intestinal peptide(VIP),motilin(MOT),creatinine(SCR),urea nitrogen(BUN)and 24-hour urinary protein(24 houtp)(P>0.05).After 2 weeks of intervention,the score of gastrointestinal symptom scale(GSRS),the content of motilin(MOT),the recovery time of gastrointestinal function,SCR and 24 h UTP in the observation group were lower than those in the control group(P<0.05);The satisfaction of patients was higher than that of the control group(P<0.05);However,there was no significant change in bun,somatostatin(SS)and vasoactive polypeptide(VIP)between the two groups before and after treatment(P>0.05).Conclusion Acupoint application of Changtong ointment in the treatment of patients with stage 3-5 chronic kidney disease with gastrointestinal complications can effectively reduce the symptoms of gastrointestinal reaction,reduce the level of gastrointestinal hormone and improve the satisfaction of patients.There is no obvious adverse reaction in clinic,so it can be popularized and applied.

关 键 词：脑-肠轴原理 肠通膏 穴位贴敷 慢性肾脏病 胃肠功能 

分 类 号：R692[医药卫生—泌尿科学]