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作 者:李娟[1] 王建成[1] 张艳华[1] 陈小红[1] 张丽丽[2] LI Juan;WANG Jiancheng;ZHANG Yanhua;CHEN Xiaohong;ZHANG Lili(Department of Laboratory,Beijing Friendship Hospital Affiliated to Capital Medical University Medicine,Beijing 100050,China;Department of Obstetrics and Gynecology,Beijing Friendship Hospital Affiliated to Capital Medical University Medicine,Beijing 100050,China)
机构地区:[1]首都医科大学附属北京友谊医院检验科,北京100050 [2]首都医科大学附属北京友谊医院妇产科,北京100050
出 处:《西部医学》2022年第10期1552-1555,F0003,共5页Medical Journal of West China
基 金:首都医科大学附属北京友谊医院“友谊种子计划”人才项目(YYZZ202019)。
摘 要:目的探讨平均血小板体积/血小板(MPVPCR)与平均血小板体积/淋巴细胞(MPVLR)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压中的预测价值。方法回顾性收集2018年1月1日~2021年1月1日我院心内科109例OSASH患者,根据患者是否合并高血压,分为单纯OSASH组及合并高血压组,比较两组患者一般基线资料;相关性分析OSAHS组及合并高血压组与基线资料的相关性;受试者工作特征曲线(ROC)分析MPVPCR及MPVLR在OSAHS合并高血压中的预测价值。结果合并高血压组与单纯OSAHS组相比,在呼吸暂停低通气指数(AHI)、最长呼吸暂停时间(LAT)、最低血氧饱和度(MinSaO_(2))水平、淋巴细胞计数、血小板(PLT)、MPVPCR及MPVLR水平上差异有统计学意义(P<0.05)。相关性表明:高AHI、高LAT、高水平MPVPCR及MPVLR水平与OSAHS发生高血压的风险呈正相关(P<0.05),而高淋巴细胞计数及高血小板水平与与OSAHS发生高血压的风险呈负相关(P>0.05)。ROC曲线分析表明MPVPCR、MPVLR单独及联合预测OSAHS发生高血压的AUC分别为0.686、0.742和0.819。结论OSAHS合并高血压组与单纯OSAHS组相比AHI、LAT更长,MPVPCR及MPVLR水平更高;MPVPCR及MPVLR是OSAHS患者发生高血压风险的独立预测因子,两者联合预测价值更高。Objective To explore the predictive value of mean platelet volume-platelet ratio(MPVPCR)and mean platelet volume-lymphocyte ratio(MPVLR)in obstructive sleep apnea hypopnea syndrome(OSAHS)with hypertension.Methods This study is a retrospective study.Patients from January 1,2018 to January 1,2021,109 with OSASH in the cardiology department of our hospital were collected.According to whether the patients had hypertension,they were divided into a simple OSASH group and hypertension group.We compared the general baseline data of the two groups.Besides,we analyzed the correlation between OSAHS and hypertension and baseline data using spearman’s correlation analysis.Finally,we analyzed the predictive value of MPVPCR and MPVLR in OSAHS with hypertension using receiver operating characteristic curve(ROC).Results Compared with the simple OSAHS group,the combined hypertension group had significant differences in the apnea-hypopnea index(AHI),the longest apnea time(LAT),minimum blood oxygen saturation(MinSaO_(2)),lymphocyte count,platelet(PLT),MPVPCR and MPVLR levels(P<0.05).The correlation showed that higher levels of AHI,LAT,MPVPCR and MPVLR were positively correlated with the risk of OSAHS hypertension(P<0.05),while higher lymphocyte count and platelet levels were negatively correlated with the risk of OSAHS hypertension.(P>0.05).ROC curve analysis showed that the AUCs of MPVPCR and MPVLR alone and in combination to predict the occurrence of hypertension in OSAHS were 0.686,0.742 and 0.819,respectively.Conclusion Compared with the OSAHS group alone,the OSAHS combined with hypertension group has longer AHI and LAT,and higher levels of MPVPCR and MPVLR;MPVPCR and MPVLR are independent predictors of the risk of hypertension in patients with OSAHS,and the combination of the two is more valuable.
关 键 词:平均血小板体积 血小板 淋巴细胞 睡眠呼吸暂停 高血压
分 类 号:R766[医药卫生—耳鼻咽喉科]
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