Prediction of Metabolic Disorders Using NMR-Based Metabolomics:The Shanghai Changfeng Study  

作　　者：Qi Wu Qing-xia Huang Hai-luan Zeng Shuai Ma Huan-dong Lin Ming-feng Xia Hui-ru Tang Xin Gao 

机构地区：[1]Department of Endocrinology and Metabolism,Zhongshan Hospital,Fudan Institute for Metabolic Disease,Human Phenome Institute,Fudan University,Shanghai 2000032,China [2]State Key Laboratory of Genetic Engineering,School of Life Sciences,Metabonomics and Systems Biology Laboratory,Human Phenome Institute,Fudan University,Shanghai 201203,China

出　　处：《Phenomics》2021年第4期186-198,共13页表型组学（英文）

基　　金：supported by the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);the Science and Technology Commission of Shanghai Municipality(16JC1400500).

摘　　要：A metabolically healthy status,whether obese or not,is a transient stage with the potential to develop into metabolic disor-ders during the course of life.We investigated the incidence of metabolic disorders in 1078 metabolically healthy Chinese adults from the Shanghai Changfeng Study and looked for metabolites that discriminated the participants who would develop metabolic disorders in the future.Participants were divided into metabolically healthy overweight/obesity(MHO)and meta-bolically healthy normal weight(MHNW)groups according to their body mass index(BMI)and metabolic status.Their serum metabolomic profile was measured using a ^(1)H nuclear magnetic resonance spectrometer(^(1)H-NMR).The prevalence of diabetes,hypertriglyceridemia,hypercholesterolemia and metabolic syndrome was similar between the MHNW and MHO participants at baseline.After a median of 4.2 years of follow-up,more MHO participants became metabolically unhealthy than MHNW participants.However,a subgroup of MHO participants who remained metabolically healthy(MHO→MHO)had a similar prevalence of metabolic disorders as the MHNW participants at the follow-up examination,despite a signifi-cant reduction in their serum concentrations of high-density lipoprotein(HDL)and an elevation in valine,leucine,alanine and tyrosine.Further correlation analysis indicated that serum intermediate-density lipoprotein(IDL)and very low-density lipoprotein cholesterol(VLDL-CH)might be involved in the transition from metabolically healthy to unhealthy status and could be valuable to identify the MHNW and MHO with increased metabolic risks.

关 键 词：Metabolically healthy normal weight(MHNW) Metabolically healthy overweight/obesity(MHO) ^(1)H nuclear magnetic resonance spectrometer(^(1)H-NMR) Metabolic disorders Very low-density lipoprotein cholesterol(VLDL-CH) Intermediate-density lipoprotein(IDL) 

分 类 号：R58[医药卫生—内分泌]