心脏移植实验研究的现状及展望  

Current status and future prospects of experimental research in heart transplantation

作　　者：王志维[1] Wang Zhiwei(Department of Cardiovascular Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心血管外科,430060

出　　处：《中华实验外科杂志》2022年第8期1429-1435,共7页Chinese Journal of Experimental Surgery

摘　　要：心脏移植是终末期心脏病最有效的治疗手段, 受限于供心来源不足、移植排斥反应等问题的限制, 心脏移植的临床开展始终受到限制。临床上遇到的困境和挑战成为实验研究的动力和方向。近年, 随着学者的努力和实验新技术的应用, 心脏移植的实验研究取得了诸多突破, 研究人员对心脏移植领域有了更深入更全面的认识, 许多实验进展逐步实现临床转化, 推动心脏移植的临床应用。本文将基于供心来源、免疫排斥机制、心脏移植物血管病变、免疫抑制治疗和术后监测等心脏移植前沿领域, 总结心脏移植实验研究进展和未来方向。Heart transplantation is the most effective treatment for end-stage heart disease,but the clinical application of heart transplantation has always been limited by problems such as insufficient donor sources and graft rejection.Clinical troubles and challenges become the driving force and direction of experimental research.In recent years,with the efforts of scholars and the application of new experimental techniques,many breakthroughs have been made in the experimental research of heart transplantation and help scholars gain a deeper and more comprehensive understanding of heart transplantation.And a lot of the experimental findings have achieved clinical translation and advanced the clinical application of heart transplantation.This review will conclude the progress and future direction of heart transplantation research in donor sources,immune rejection,cardiac allograft vasculopathy,immunosuppressive therapy,and postoperative monitoring.

关 键 词：心脏移植 排斥反应 心脏移植物血管病 免疫抑制治疗 

分 类 号：R654.2[医药卫生—外科学] R-332[医药卫生—临床医学]