恒河猴(Macaca mulatta)生殖周期内性类固醇激素分泌规律的研究  

STUDY ON SECRETION OF SEX STEROIDS OF RHESUS MONKEY (MACACA MULATTA) IN MENSTRUAL CYCLES

作　　者：季维智[1] 邹如金[1] 严晔[1] 杨克勤 吴光瑛[2] 王伯苓[2] 孔凌[2] Ji Weizhi;Zou Rujiu;Yan Ye;Yong Kejin;Wu Gungyin;Wang Bolin;Kong ling(Kunming Institute of Zoology,Academia sinica;The First Hospital Attached to Kunming Medical College)

机构地区：[1]中国科学院昆明动物研究所 [2]昆明医学院第一附属医院

出　　处：《Zoological Research》1988年第1期29-36,共8页动物学研究（英文）

基　　金：国家自然科学基金。

摘　　要：本文用放射免疫测定法对7只雌性恒河猴(Macaca mulatta)的20个月经周期进行了雌二醇、孕酮和睾酮的动态测定分析,其中15个月经周期的中期都有睾酮和雌二醇峰(其峰值分别为1010.7±411.3pg/ml和179.1±91.3pg/ml),孕酮在黄体期的峰值为2.54±0.65ng/ml。正常黄体期的血清孕酮水平不低于1ng/ml。20个月经周期的平均天数为28.6±5.4天,滤泡期和黄体期分别为11.9±2,6和19.2±6.3天。月经周期可用公式Y=18.92±0.03×X^(2)(Y:月经周期,X:黄体期。R=0.9444)表示。实验结果表明,测定周期内三种性类固醇激素可以准确确定排卵。睾酮在生殖周期内的分泌调节机制还待进一步研究。The concentration of sex steroids in the serum of 7 females rhesus monkeys during the intermenstrual period were measured by radioimmunoassay.Fifteen of 20 menstrual cycles have a surge of estradiol and testosterone in the middle cycles.The average surge value of estradiol and testosterone are 179.1±91.3 pg/ml and 1010.1±411.3 pg/ml respectively.In normal luteal phase,the value of progesterone is not below 1 ng/ml.The average length of 20 menstrual cycles is 28.6±5.4 days(mean±SD).Follicle phase is 11.9±2.8 days.Luteal phase is 19.2±6.3 days.The menstrual cycles are expressed by the formula Y=18.92±0.03X^(2)(Y:menstrual cycle,X:luteal phase,R=0.9444).The results suggest that mesuring the three steroids hormones can be accurately indexed ovulatory in rhesus monkeys.The mechanism of secretion and regulation of testosterone in reproductive cycle will be studied continuously.

关 键 词：恒河猴(Macaca mulatta) 月经周期 雌二醇 孕酮 睾酮 

分 类 号：R71[医药卫生—妇产科学]