Plasma Lipidomic Subclasses and Risk of Hypertension in Middle-Aged and Elderly Chinese  

作　　者：Zhenhua Niu Qingqing Wu Yaogan Luo Di Wang He Zheng Yanpu Wu Xiaowei Yang Rong Zeng Liang Sun Xu Lin 

机构地区：[1]Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,320 Yue-yang Rd.,Shanghai 200031,China [2]Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China [3]Key Laboratory of Systems Biology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou 310024,China [4]Key Laboratory of Systems Health Science of Zhejiang Province,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou 310024,China

出　　处：《Phenomics》2022年第5期283-294,共12页表型组学（英文）

基　　金：The study was supported by the Strategic Priority CAS Project(XDB38000000);the Ministry of Science and Technology of China(2017YFC0909701);the National Natural Science Foundation of China(81561128018,81700700,and 81970684);the Chinese Academy of Sciences(KSCX2-EW-R-10,KJZD-EW-L14-2-2);Shanghai Municipal Science and Technology Major Project(2017SHZDZX01).

摘　　要：While disrupted lipid metabolism is a well-established risk factor for hypertension in animal models,the links between various lipidomic signatures and hypertension in human studies remain unclear.We aimed to examine associations between plasma lipidomic profiles and prevalence of hypertension among 2248 community-living Chinese aged 50-70 years.Hypertension was defined according to 2020 International Society of Hypertension global hypertension practice guidelines and 2018 Chinese guidelines.In total,728 plasma lipidomic species were profiled using high-coverage targeted lipidomics.After multivariate adjustment,including lifestyle,body mass index,blood lipids,and sodium intake,110 metabolites from nine lipidomic subclasses showed significant associations with hypertension,among which phosphatidylethanolamines(PEs)had the strongest association.Eleven lipidomic signals for hypertension risk were further identified from the nine subclasses,including PE(18:0/18:2)(OR per SD,1.49;95%confidence intervals,1.30-1.69),phosphatidylcholine(PC)(18:0/18:2)(1.27;1.13-1.43),phosphatidylserine(18:0/18:0)(1.24;1.09-1.41),lysophosphatidylinositol(18:1)(1.17;1.06-1.29),triacylglycerol(52:5)(1.38;1.18-1.61),diacylglycerol(16:0/18:2)(1.42;1.19-1.69),dihydroceramide(24:0)(1.25;1.09-1.43),hydroxyl-sphingomyelins(SM[2OH])C34:1(1.19;1.07-1.33),lysophosphatidylcholine(20:1)(0.86;0.78-0.95),SM(OH)C38:1(0.87;0.79-0.96),and PC(18:2/20:1)(0.84;0.75-0.94).Principal component analysis also showed that a factor mainly containing specific PEs was positively associated with hypertension(1.20;1.09-1.33).Collectively,our study revealed that disturbances in multiple circulating lipidomic subclasses and signatures,especially PEs,were significantly associated with the prevalence of hypertension in middle-aged and elderly Chinese.Future studies are warranted to confirm our findings and determine the mechanisms underlying these associations.

关 键 词：HYPERTENSION Lipidomic profiles PHOSPHATIDYLETHANOLAMINES Asian population 

分 类 号：R544.1[医药卫生—心血管疾病]