120例血液透析患者尿毒症瘙痒症发生情况及影响因素分析  

Analysis of the Occurence Condition and Influencing Factors of Uremia Pruritus in 120 Hemodialysis Patients

作　　者：陈晴 陈仁芬 谢丽红 蒋小妹 CHEN Qing;CHEN Renfen;XIE Lihong;JIANG Xiaomei(Longyan People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Longyan 364000,China)

机构地区：[1]福建中医药大学附属龙岩人民医院,福建龙岩364000

出　　处：《中外医学研究》2022年第26期162-165,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：龙岩市科技创新联合资金卫生项目(2020LYF17012)。

摘　　要：目的:分析120例血液透析患者尿毒症瘙痒症(UP)发生情况及影响因素。方法:选取福建中医药大学附属龙岩人民医院2020年1月-2021年6月收治的120例血液透析患者作为研究对象。根据有无UP对所有患者进行分组,收集所有患者基线资料及实验室指标。统计分组情况,对血液透析患者UP的发生进行单因素及多因素分析。结果:120例患者中,56例发生UP纳入UP组,发生率为46.67%,64例未发生UP纳入非UP组。UP组糖尿病肾病占比、甲状旁腺激素、血磷、C反应蛋白、β_(2)-微球蛋白水平均明显高于非UP组,HDF/HD+HP、Kt/V≥1.5占比均明显低于非UP组(P<0.05)。Logistic结果显示,血磷、甲状旁腺激素、C反应蛋白、β_(2)-微球蛋白、糖尿病肾病均是血液透析患者发生UP的独立危险因素(P<0.05),HDF/HD+HP、Kt/V≥1.5均是血液透析患者发生UP的保护因素(P<0.05)。结论:血液透析患者易出现UP,糖尿病肾病及高水平血磷、甲状旁腺素、C反应蛋白、β_(2)-微球蛋白患者是UP发生的高危人群,而采取HDF/HD+HP及提高Kt/V有助于减少UP的发生,值得临床重视。Objective:To analyze the occurence condition and influencing factors of uremia pruritus(UP)in 120 hemodialysis patients.Method:A total of 120 hemodialysis patients admitted to Longyan People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2020 to June 2021 were selected as the research objects.All patients were grouped according to whether there was UP,and the baseline data and laboratory indicators of all patients were collected.The grouping situation was counted,univariate and multivariate analysis of the occurence of UP in hemodialysis patients were performed.Result:Among 120 patients,56 patients with UP were included in the UP group,with an incidence of 46.67%,and 64 patients without UP were included in the non UP group.The proportion of diabetes nephropathy,parathyroid hormone,blood phosphorus,C-reactive protein,β_(2)-microglobulin levels were significantly higher than those in non UP group,and the proportions of HDF/HD+HP and Kt/V≥1.5 were significantly lower than those in non UP group(P<0.05).The Logistic results showed that blood phosphorus,parathyroid hormone,C-reactive protein,β_(2)-microglobulin and diabetes nephropathy were independent risk factors for the occurence of UP in hemodialysis patients(P<0.05),HDF/HD+HP and Kt/V≥1.5 were protective factors for occurence of UP in hemodialysis patients(P<0.05).Conclusion:Hemodialysis patients are prone to the occurence of UP,patients with diabetes nephropathy,high levels of blood phosphorus,parathyroid hormone,C-reactive protein,β_(2)-microglobulin are high-risk groups for the occurrence of UP,and adopting HDF/HD+HP and increasing Kt/V can help to reduce the occurrence of UP,which is worthy of clinical attention.

关 键 词：血液透析 尿毒症瘙痒症 影响因素 LOGISTIC回归分析 

分 类 号：R692.5[医药卫生—泌尿科学]