青岛市成年人体质指数与冠心病发病关联的前瞻性研究  

Association between body mass index and coronary heart disease in Qingdao:a prospective study

作　　者：宋佳慧 潘驰 李斐斐[2] 薛晓嘉 郭彧[3] 裴培[3] 田小草[2,4] 汪韶洁 高汝钦[1,5] 逄增昌 陈铮鸣[6] 李立明[7,8] Song Jiahui;Pan Chi;Li Feifei;Xue Xiaojia;Guo Yu;Pei Pei;Tian Xiaocao;Wang Shaojie;Gao Ruqin;Pang Zengchang;Chen Zhengming;Li Liming(Department of Nutrition and Food Hygiene,School of Public Health,Qingdao University,Qingdao 266071,China;Department of Non-communicable Disease Control and Prevention,Qingdao Prefectural Center for Disease Control and Prevention,Qingdao 266033,China;Chinese Academy of Medical Sciences,Beijing 100730,China;Qingdao Institute of Preventive Medicine,Qingdao 266033,China;Qingdao Prefectural Center for Disease Control and Prevention,Qingdao 266033,China;Clinical Trial Service Unit and Epidemiological Studies Unit,Nuffield Department of Population Health,University of Oxford,Oxford OX37LF,UK;School of Public Health,Peking University,Beijng 100191,China;Peking University Center for Public Health and Epidemic Preparedness&Response,Beijing 100191,China)

机构地区：[1]青岛大学公共卫生学院营养与食品卫生学系,青岛266071 [2]青岛市疾病预防控制中心慢性非传染病防制科,青岛266033 [3]中国医学科学院,北京100730 [4]青岛市预防医学研究院,青岛266033 [5]青岛市疾病预防控制中心,青岛266033 [6]英国牛津大学临床与流行病学研究中心纳菲尔德人群健康系,牛津OX37LF [7]北京大学公共卫生学院,北京100191 [8]北京大学公众健康与重大疫情防控战略研究中心,北京100191

出　　处：《中华流行病学杂志》2022年第9期1357-1363,共7页Chinese Journal of Epidemiology

基　　金：国家重点研发计划精准医学研究重点专项(2016YFC0900500,2016YFC0900501,2016YFC0900504);中国香港Kadoorie Charitable基金;英国Wellcome Trust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z);青岛市医疗卫生优秀人才培养项目。

摘　　要：目的分析青岛市成年人体质指数(BMI)与冠心病发病之间的关联。方法研究对象来自中国慢性病前瞻性研究青岛市项目点,共纳入33355名30~79岁研究对象,采用Cox比例风险回归模型,分析BMI与冠心病发病的关联。结果调查对象平均随访9.2人年,共监测缺血性心脏病(IHD)2712例,主要冠心病事件(MCE)420例。多因素Cox回归分析显示,与体重正常或过低的人群相比,超重和肥胖人群IHD及MCE的风险增加,超重组发病风险分别增加了41%和87%,HR值(95%CI)分别为1.41(1.27~1.56)和1.87(1.43~2.44),肥胖组分别增加了91%和143%,HR值(95%CI)分别为1.91(1.72~2.13)和2.43(1.82~3.24)。结论超重和肥胖会增加IHD和MCE的发病风险。Objective To analyze the association between body mass index(BMI)and coronary heart disease.Methods The data for the present study were from the prospective cohort study of China Kadoorie Biobank(CKB)in Qingdao,a total of 33355 participants aged 30-79 years were included in the study.Cox regression analyses were performed to evaluate the association between BMI and coronary heart disease.Results During the follow-up for an average 9.2 years,a total of 2712 cases of ischemic heart disease(IHD)and 420 cases of major coronary events(MCE)were found.Multivariate Cox regression analysis showed that,compared with participants with normal BMI,the participants who were overweight had a 41%and 87%higher risk of IHD and MCE,the adjusted HR were 1.41(95%CI:1.27-1.56)and 1.87(95%CI:1.43-2.44),respectively.The participants who were obesity had 91%and 143%higher risk of IHD and MCE,the adjusted HR were 1.91(95%CI:1.72-2.13)and 2.43(95%CI:1.82-3.24),respectively.Conclusion Overweight and obesity might increase the risk for IHD and MCE.

关 键 词：体质指数 冠心病 前瞻性研究 

分 类 号：R541.4[医药卫生—心血管疾病]