纳米药物调控巨噬细胞增强肿瘤免疫治疗的研究进展  

Recent progress of nanoparticle-enabled modulation of macrophages for cancer immunotherapy

作　　者：冯靖澜 杨凯 胡家润 苏耘禾 罗锐童 潘昱东 罗佳琪 张京扬 杜金志 FENG Jing-lan;YANG Kai;HU Jia-run;SU Yun-he;LUO Rui-tong;PAN Yu-dong;LUO Jia-qi;ZHANG Jing-yang;DU Jin-zhi(School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou 511442,China;School of Medicine,South China University of Technology,Guangzhou 510006,China)

机构地区：[1]华南理工大学生物医学科学与工程学院,广东广州511442 [2]华南理工大学医学院,广东广州510006

出　　处：《药学学报》2022年第9期2654-2661,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(51922043,52173122).

摘　　要：巨噬细胞在维持机体稳态过程中起着重要作用。巨噬细胞是肿瘤微环境中最丰富的免疫细胞之一,通常被称作肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs),其在肿瘤发生发展过程中发挥重要作用,也是肿瘤治疗的重要靶点。研究表明,通过调控巨噬细胞功能可实现抑制肿瘤生长、转移等,但其治疗药物往往存在缺乏靶向性、溶解度较差、生物利用度低、不良反应大等问题。本文在介绍巨噬细胞与肿瘤治疗相关背景的基础上,重点关注纳米药物递送系统在调控巨噬细胞功能增强肿瘤免疫治疗的研究进展。纳米药物递送系统结构丰富、功能多样,可通过多种途径调控巨噬细胞功能,提高抗肿瘤治疗效果。本文将分别从靶向清除TAMs、重极化TAMs、促进TAMs吞噬,以及联合调控TAMs功能等方面,综述近年来基于纳米药物递送系统的调控策略及典型例子,同时对这一领域的未来研究方向进行了展望。Macrophages play an important role in maintaining homeostasis of the body,and they are also one of the most abundant immune cells in the tumor microenvironment(TME).These macrophages are often called tumor-associated macrophages(TAMs),which play an important role in the development of tumor and are an important target for tumor therapy.Studies have shown that tumor growth and metastasis can be inhibited by regulating the function of macrophages,but the therapeutic efficacy was often hampered by the poor performance of the drugs such as lack of targeting,poor solubility,low bioavailability,and severe side effects.After introduction of the background of macrophage and tumor therapy,this review focuses on the research progress of nano-drug delivery systems in the modulation of the function of macrophages to enhance tumor immunotherapy.Nano-drug delivery systems are diverse in structures and functions,and can regulate macrophage functions through a variety of mechanisms.Four important aspects of macrophage modulation,which included TAMs depletion,repolarization of TAMs,promoted phagocytosis of TAMs,and combinational modulation of TAMs were summarized.Each strategy together with typical examples was reviewed and future directions in this field were also prospected.

关 键 词：纳米粒 药物载体 巨噬细胞 肿瘤治疗 吞噬作用 

分 类 号：R945[医药卫生—微生物与生化药学]